유리체강내 주입술 후 급성 안내염의 발생 빈도와 임상 양상

• 영문명: Incidence and Characteristics of Acute Endophthalmitis Associated With Intravitreal Injection
• 발행기관: 대한안과학회
• 저자명: 김현진 이동원 강효정 유영주 최문정 한정일 유수진 조성원 이태곤 이재흥
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume50,number7, 1060~1065쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.07.15

영문 초록

Purpose: To evaluate the incidence, causative organism, clinical features, and visual outcomes of acute endophthalmitis following intravitreal injection. Methods: For all intravitreal triamcinolone acetonide, bevacizumab, and lucentis injections performed in our outpatient clinic between January 2006 and June 2008, the number of injections, indications, type of administered drugs, and method of injection were investigated. The medical records of the patients with acute endoththalmitis were reviewed retrospectively. Results: The total number of intravitreal injections was 10,153. The incidence of acute endophthalmitis for all intravitreal injections was 0.020% (2/10,153) with 0.030% (1/3,383) for the triamcinolone acetonide, 0.015% (1/6,552) for the bevacizumab, and 0.000% (0/218) for the ranibizumab drug injections. Streptococcus species were confirmed in the bacterial culture of two eyes with acute endotphthalmitis. After early vitrectomy and intravitreal antibiotics injection, one eye maintained vision but the other eye developed phthisis. Conclusions: Although the incidence of acute endophthalmitis following intravitreal injections performed in outpatient clinics is very low, due to the potentially fatal visual outcome after endophthalmitis, careful attention to aseptic injection technique is mandatory.

키워드

Anti-VEGF, Endophthalmitis