보툴리눔 A 독소 테논낭하 주사가 가토 외안근에 미치는 영향

• 영문명: Morphological Changes in Extraocular Muscle of Rabbit Eye Produced by Subtenon`s Botulinum A Toxin Chemodenervation
• 발행기관: 대한안과학회
• 저자명: 하병진 김용민 권현석 장윤희 한승한 주영광 박종운 임찬영
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume47,number2, 305~311쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.02.28

영문 초록

Purpose: Currently, when injecting botulinum a toxin into the extraocular muscle, EMG (Electromyography) is used for accurate location. In this study, we examined the effects of subtenon botulinum toxin injection without EMG guidance by quantifying the morphological changes of the extraocular muscle fibers in rabbits. Methods: Using 10 New Zealand white rabbits, 10 units of botulinum a toxin in 0.1 ml of normal saline was injected into the subtenon space of the superior rectus muscles, 5 mm from the muscle insertion in right eyes. As a control, 0.1 ml of normal saline was injected into the subtenon space of the superior rectus muscles in left eyes. At 3 weeks after injections, the bilateral superior rectus muscles of each rabbit were carefully dissected from the globe. Cross-sections of 5 ?m thickness were obtained at the site, 5 mm from the insertion of each superior rectus muscle. Sections were stained with Masson`s trichrome and observed by light microscopy. Using Image-Pro Plus software, the diameter of the orbital layer myofibers was measured and statistical analysis was done using the Kruskal-Wallis test. Results: The average diameter of the orbital layer fiber cells after botulinum toxin injection was 11.5±2.26 ?m at 3 weeks, whereas that of the control was 14.4±3.77 ?m. The difference was statistically significant (p<0.01). Conclusions: The diameter of myofibers in the orbital layer was reduced after subtenon botulinum a toxin injection. Further studies on the duration of botulium toxin in subtenon space and the change in the size of myofibers depending on the dosage of botulinum toxin will be necessary.

키워드

Botulinum a toxin, Chemodenervation, Extraocular Muscle, Subtenon`s injection.