항진균 알릴아민 유도체의 합성과 생물학적 평가

• 영문명: Synthesis and Biological Evaluation as a Potential Antifungal Allylamine Derivatives
• 발행기관: 대한약학회
• 저자명: 정병호(Byung-Ho Chung) 정순영(Soon-Young Chung)
• 간행물 정보: 『약학회지』제48권 제4호 (2004년), 254~260쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2004.08.31

영문 초록

Structure-activity relationship studies of allylamine type of antimycotics were carried out to evaluatefhe effect of naphthyl and methyl portion of naftifine. Compounds with 2,4-difluorophenyl(2a-5a) , 2,5-difluorophenyl(2b-5b), 4-eth- ylphenyl(2c-5c), 2-hydroxyphenyl(2d-5d) and 2-methylnaphthyl(2e-5e) instead of naphthyl group with hydrogen(3a-3e), methyl(4a-4e), and ethyl(5a-5e) in the place of methyl in naftifine were synthesized and tested their in vitro anti-fungal activity against five different fungj. Eight compounds(3a,4a,5a,3d,4d,4d,5d,3e, and 4e) showed significant anti-fungal activity against T. mentagrophytes. (E)-N-(3-Phenol-2-propenyl) -2- hydroxy-benzenemethaneamine(3d) displayed moderate antifungal activity against all five different fungi.

키워드

trans-cinnamylamine 2,4-difluorobenzaldehyde 3-nitrobenzaldehyde