경도인지장애, 알쯔하이머병에서 혈장 Homocysteine, Folate, Vitamin B12 농도와 인지기능

• 영문명: Serum Levels of Homocysteine, Folate, and Vitamin B12 and Cognitive Function in Mild Cognitive Impairment and Alzheimer's Disease
• 발행기관: 대한노인정신의학회
• 저자명: 이재혁(Jae Hyuk Lee) 이강준(Kang Joon Lee) 김현(Hyun Kim)
• 간행물 정보: 『노인정신의학』노인정신의학 제14권 제1호, 44~49쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2010.06.30

영문 초록

Objectives : This study aimed to investigate the serum levels of total homocysteine (tHcy), folate and vitamin B12 in Alzheimer's disease and mild cognitive impairment. Methods : Sixty-one Alzheimer's disease (AD) patients, forty mild cognitive impairment (MCI) patients and forty-four normal controls were studied. The serum homocysteine (tHcy), folate, and vitamin B12 were measured and MMSE-K, GDS were evaluated for cognitive function. Results : Serum tHcy levels were significantly higher and folate levels were lower in patients with AD than in controls. And also serum folate levels were lower in MCI than in controls. Vitamin B12 did not have a significant difference among three groups. The serum homocysteine and folate levels shows significant correlation with MMSE-K. Conclusion : Elevated tHcy levels and low blood levels of folate were associated with AD. Serum folate were significantly lower levels in MCI than in controls. We suggested that serum tHcy, folate are useful risk markers for the development of cognitive dysfunction.

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호모시스테인 엽산 비타민 B12 알쯔하이머병 경도인지장애 Homocysteine Folate Vitamin B12 Alzheimer's disease Mild cognitive impairment