The effect of biological mechanisms of melatonin on the proliferation of spermatogonial stem cells: a systematic review

• 영문명: The effect of biological mechanisms of melatonin on the proliferation of spermatogonial stem cells: a systematic review
• 발행기관: 대한해부학회
• 저자명: Shadan Navid Zahra Saadatian Ali Talebi Heidar Toolee Saba Seyedi
• 간행물 정보: 『Anatomy and Cell Biology』Vol.57(2), 163~171쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2024.06.30

국문 초록

In the last decade, melatonin has gained recognition as a potent scavenger and an effective antioxidant capable of neutralizing free radicals, including reactive oxygen species. Additionally, it exhibits anti-apoptotic properties. In this review, we will examine a compilation of articles that explore the cellular signaling function of melatonin on spermatogonial stem cells (SSCs) and adjacent cells such as Sertoli and Leydig cells. These cells play a crucial role in the proliferation of SSCs both in vitro and in vivo. In this review, we analyze the function of melatonin in the proliferation of SSCs from other aspects. For this purpose, we examine the articles based on the presence of melatonin on SSCs in four groups: As a supplement in SSCs medium culture, SSCs three-dimensional culture system, SSCs freezing medium, and as a therapeutic factor in vivo. Mechanisms of growth and proliferation of SSCs were considered. The purpose of this study is to investigate the potential effects of melatonin as a powerful antioxidant or growth stimulant for SSCs, both in vivo and in vitro.

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키워드

Melatonin Spermatogonial stem cells Proliferation