Mitophagy stimulation as a novel strategy for the treatment of mitochondrial diseases

• 영문명: Mitophagy stimulation as a novel strategy for the treatment of mitochondrial diseases
• 발행기관: 대한의학유전학회
• 저자명: Kang-Min Lee Jeanho Yun
• 간행물 정보: 『대한의학유전학회지』제19권 제2호, 49~56쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2022.12.31

영문 초록

Mitophagy, the selective degradation of damaged or surplus mitochondria using core autophagy machinery, plays an es-sential role in maintaining cellular mitochondrial function. Impaired mitophagy is closely linked to various human diseases, including neurodegenerative diseases, cardiovascular diseases, cancers and kidney disease. Defective mitophagy induces the accumulation of damaged mitochondria and thereby results in a decline in cellular survival and tissue function. Accordingly, enhancement of mitophagy has been proposed as a novel strategy for the treatment of human diseases closely linked to mi-tochondrial dysfunction. Recent studies showing that the stimulation of mitophagy has a therapeutic effect on several disease models highlight the possibility of disease treatment using mitophagy. The development of mitophagy inducers with toxicity and the identification of molecular mechanisms will enable the clinical application of mitophagy-based treatments.

목차

Introduction

Mitophagy Defects in Human Diseases

Therapeutic Effect of Mitophagy Stimulation

Concluding remarks/prospective

Acknowledgements

Authors’ Contributions

References

키워드

Mitophagy Mitochondrial disease Drug development