Preventive Effect of Traditional Korean Formulations on Intimal Thickening of Rat Carotid Artery Injured by Balloon Catheter

• 발행기관: 한국자원식물학회
• 저자명: Seong Bin Kim Keshav Raj Paudel Dong Wook Kim
• 간행물 정보: 『한국자원식물학회지』제26권 제6호, 678~685쪽, 전체 8쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2013.12.30

영문 초록

The objective of this study was to examine the effect of 7 traditional Korean formulations (7TKFs) on intimalthickening of rat carotid artery injured by balloon catheter in vivo and on the proliferation of human smooth muscle cells(HASMCs) and secretion of matrix metalloproteinase-2 (MMP-2) in vitro. 7TKFs (400 mg/kg) were administered orally for4 weeks from the day of balloon injury in the rats. HASMC proliferation was assessed by 3-(4,5-dimethylthiazol-2)-2,5-diphenyltetrazolium bromide (MTT) assay while enzymatic action of MMP-2 was carried out by gelatin zymography. Among 7TKFs, Samhwang-sasim-tang (SST), Banha-sasim-tang (BST) and Kegi-honghwa-tang (KHT) significantlyreduced the intimal thickening by suppressing HASMC proliferation and MMP-2 expression in both extracellular andintracellular levels. Thus, the results suggest that SST, BST and KHT can be considered as a therapeutic value in theprevention of atherosclerosis because restenosis after PTCA (percutaneous transluminal coronary angioplasty) is supposedto be ‘accelerated atherosclerosis’.

목차

Introduction

Materials and Methods

Results and Discussion

Literature Cited

키워드

PTCA 7TKFs Intimal thickening HASMC