Magnetic Resonance Imaging as a Biomarker for Duchenne Muscular Dystrophy

• 발행기관: 한국전문물리치료학회
• 저자명: Woo taek Lim
• 간행물 정보: 『한국전문물리치료학회지』한국전문물리치료학회지 제22권 제3호, 98~105쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2015.09.30

영문 초록

Muscular dystrophy is a hereditary musculoskeletal disorder caused by a mutation in the dystrophin gene. Duchenne muscular dystrophy (DMD) is one of the most common, and progresses relatively faster than other muscular dystrophies. It is characterized by progressive myofiber degeneration, muscle weakness and ultimately ambulatory loss. Since it is an X-linked recessive inheritance, DMD is mostly expressed in males and rarely expressed or less severe in females. The most effective measurement tool for DMD is magnetic resonance imaging (MRI), which allows non-invasive examination of longitudinal measurement. It can detect progressive decline of skeletal muscle size by measuring a maximal cross-sectional area of skeletal muscle. Additionally, other techniques in MRI, like T2-weighted imaging, assess muscle damage, including inflammation, by detecting changes in T2 relaxation time. Current MRI techniques even allow quantification of metabolic differences between affected and non-affected muscles in DMD. There is no current cure, but physical therapist can improve their quality of life by maintaining muscle strength and function, especially if treatment (and other forms of medical intervention) begins in the early stages of the disease.

목차

Abstract

Introduction

Invasive Measurement

Non-Invasive Measurements

Conclusion

References

키워드

Duchenne muscular dystrophy Eccentric exercise Fatty infiltration Inflammation Magnetic resonance imaging Muscle damage Muscular dystrophy