파라퀴논 유도체와의 전하이동착물 형성을 이용한 에녹사신 정량

• 영문명: The Determination of Enoxacin with p-Quinone Derivatives
• 발행기관: 대한약학회
• 저자명: 이지연(J. Y. Lee) 김동오(D. O. Kim) 남수자(S. J. Nam) 정문모(M. M. Jung) 허문회(M. H. Hur) 안문규(M. K. Ahn)
• 간행물 정보: 『약학회지』제43권 제4호 (1999년), 437~441쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.08.28

영문 초록

Enoxacin[1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid, ENX is a new quinolone antibacterial agent. The method is based on the highly colored charge-transfer complex formation of this drug as a pi-electron donor with 7,7,8,8-tetracyanoquinodimethane(TCNQ) or chloranil(CL) as pi-acceptors. The colored products were measured spectrophotometrically at 842nm and 552nm for TCNQ and CL, respectively. The different experimental conditions are optimized. The linearities for TCNQ and CL were 1.6mcg/mL~32mcg/mL and 6.4mcg/mL~160mcg/mL, respectively and colors were produced in non-aqueous media. This report describes a simple and rapid method for the analysis of enoxacin.

키워드

Enoxacin quinolone 7,7,8,8-tetracyanoquinodimethane chloranil charge-transfer complex.