사염화탄소로 독성을 유발시킨 일차배양 간세포에 미치는 G009의 효과

• 영문명: Hepatoprotective Effect of G009 on CCl4-induced Hepatotoxicity in Primary Cultured Rat Hepatocytes
• 발행기관: 대한약학회
• 저자명: 이미경(Mi Kyeong Lee) 김홍표(Hong Pyo Kim) 이준우(June Woo Lee) 정훈(Hoon Jung) 이승룡(Seoung Yong Lee) 김영중(Young Choong Kim)
• 간행물 정보: 『약학회지』제42권 제1호 (1998년), 108~113쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.01.31

영문 초록

G009, a polysaccharide isolated from the mycelia of Ganoderma lucidum IYO09, showed a hepatoprotective activity against CCl4 induced cytotoxicity in primary cultured rat hepatocytes. Incubation of CCl4-intoxicated hepatocytes with G009 significantly reduced the levels of glutamic pyruvic transaminase and sorbitol dehydrogenase released from hepatocytes in the medium. G009 showed antioxidative effect by elevating the activities of glutathione reductase and superoxide dismutase, and the content of glutathione in CCl4-intoxidcated primary cultured rat hepatocytes. Furthermore, G009 significantly elevated glutathione-S-transferase activity in CCl4-intoxicated primary cultured rat hepatocytes. G009 also reduced the production of malondialdehyde, a byproduct of lipid peroxidation. From these results, it could be concluded that G009 exerted hepatoprotective activity against CCl4-induced cytotoxicity through antioxidation.

키워드

G009 primary cultured rat hepatocytes CCI4 glutamic pyruvic transaminase sorbitol dehydrogenase glutathione reductase glutathione superoxide dismutase glutathione-S-transferase malondialdehyde.