케토프로펜 겔제와 플라스터제의 피부 흡수 비교

• 영문명: The Topical Absorption of Ketoprofen from Gels and Plaster in Human Volunteers
• 발행기관: 대한약학회
• 저자명: 강원구(W. K. Kang) 이창현(C. H. Lee) 우종수(J. S. Woo) 권광일(K. I. Kwon)
• 간행물 정보: 『약학회지』제42권 제1호 (1998년), 25~30쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.01.31

영문 초록

This study was designed to compare the absorption fraction and extent of ketoprofen gels and a matrix typed ketoprofen plaster patch. 3g (90mg as ketoprofen) of the two gels which has oleohydrogel or hydrogel as a base, respectively, and 3 pieces of plaster patches (90mg as ketoprofen) were, applied in the area of 210cm2 on forearm in 12 volunteers by cross over design. Blood samples were collected serially up to 24 hours and the plasma concentrations of ketoprofen were analyzed by HPLC using flurbiprofen as an internal standard. The detection limit of the assay was 1ng/ml of ketoprofen in plasma. The pharmacokinetic parameters (e.g. AUC24hr, AUMC24hr, MRT, Fraction Absorbed) were calculated from the plasma concentrations time data of each volunteer. The oleo-hydrogel showed significantly higher absorption fraction and extent of ketoprofen than the current hydrogel. The mean plasma concentrations of the oleo-hydrogel were increased to 98.46+/-23.15ng/ml by 6 hour after application, and increased futher to 100.61+/-18.65ng/ml at 24 hour. On the other hand, those of the hydrogel were increased 17.61+/-18.65ng/ml at 5 hour to 34.68+/-9.65ng/ml at 24 hour gradually. Therefore the plasma concentrations of oleo-hydrogel at each measured time were 3~7 times greater than those of the hydrogel with statistical significance. The AUC24hr (1797.26+/-52.09ng.h/ml) of the oleo-hydrogel was 3.5 times greater (P<0.05) than that (516.17+/-104.52ng.h/ml) of the hydrogel. The plaster patches showed higher bioavailability (AUC24hr 2877.37+/-578.27ng.h/ml) than the olea-hydrogel (AUC24hr 1797.26+/-52.09ng.h/ml) without statistical significance. But the absorption fraction of the oleo-hydrogel was rather higher than that of the plaster patches during the first 6 hours after administration. These results suggest that newly developed ketoprofen gel which is used oleo-hydrogel as a base would show excellent skin permeation on topical application for the corresponding clinical indications and could be absorbed as well as plaster patches.

키워드

Ketoprofen flurbiprofen oleo-hydrogel skin absorption pharmacokinetics.