역합성법에 의한 진세노사이드 유사체의 합성

• 영문명: Retro-synthesis of Analogues of Ginsenosides
• 발행기관: 대한약학회
• 저자명: 장은하(Eun Ha Chang) 제남경(Nam Gyung Je) 임광식(Kwang Sik Im)
• 간행물 정보: 『약학회지』제40권 제2호 (1996년), 163~169쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.04.30

영문 초록

Glycosidation of 20(S)-protopanaxadiol obtained by the alkaline hydrolysis of total ginsenosides with 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide in the presence of CdCO3 in benzene-dioxane gave a mixture of acetylated monoglucosides and diglucosides in a total yield of 68%. Under the same condenstion condition, 20-dehydroxyglucosides were formed by dehydration of 12-O-glucosides. The structures of produced glycosides were elucidated as 3-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, 12-O-beta-D-glucopyranosyl-dammar-20(22), 24-dien-3beta,12 beta-diol, 3,12-di-O-beta-D-glucopyranosyl-dammar-20(22), 24-dien-3beta, 12beta-diol, respectively.

키워드

Total ginsenosides retro-synthesis analogues of ginsenosides 13C-NMR.