인삼 석유에텔 추출물이 흰쥐에서 Benzo(a)pyrene에 의해 유도된 소핵생성의 억제효과

• 영문명: Suppressive effect of Petroleum Ether Extract of Panax ginseng against Benzo(a)pyrene induced Micronuclei in Mice
• 발행기관: 대한약학회
• 저자명: 최성규(Sung Gyu Choi) 김천호(Cheon Ho Kim) 허문영(Moon Young Heo)
• 간행물 정보: 『약학회지』제35권 제6호 (1991년), 466~472쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.12.30

영문 초록

Petroleum ether extracts of panax ginseng C.A. Meyer (GPEE) were tested for the evaluation of anticlastogenic effects against benzo(a)pyrene-induced micronucleated polychromatic erythrocytes using mouse bone marrow micronucleus test. When the GPEE was singly administered before benzo(a)pyrene injection, GPEE showed significant anticlastogenic effect at 50-200mg/kg. When the GPEE was multiply administered for 5 consecutive days before benzo(a)pyrene injection, GPEE showed potent anticlastogenic effect, even at the low doses, 5-50mg/kg/day. As a control experiment, GPEE was administered without benzo(a)pyrene injection to demonstrate a clastogenic effect of this extract. When the range of 1-200mg/kg/day for 5 consecutive days was administered to mice, it was found that there was no increase of MNPCEs frequency.

키워드

Panax ginseng C.A. Meyer petroleum ether extract benzo(a)pyrene micronucleus test anticlastogenic effect.