생쥐 췌조직내 Protein Methylase에 대한 자율신경계약물의 영향

• 영문명: Effect of Adrenergic and Cholinergic Agents on the Activities of Protein Methylases in Pancreatic Tissue
• 발행기관: 대한약학회
• 저자명: 유태무(Tae Moo Yoo) 박선미(Sun Mee Park) 이향우(Hyang Woo Lee)
• 간행물 정보: 『약학회지』제35권 제4호 (1991년), 341~347쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.08.30

영문 초록

It was reported that protein carboxymethylation is involved in amylase secretion of parotid gland by isoproterenol. It was also suggested that a small part of the total cellular protein carboxymethylation is directly involved in pancreatic enzyme secretion. On the contrary, other authors reported that there is no relationship between protein carboxymethylation and secretion in pancreas and parotid gland. In recent study, it was proposed that a methyl acceptor protein plays a limited modulatory role in the coupling of cytosolic Ca++ accumulate on and exocytosis. In this study, the effects of cholinergic and adrenergic agents on the activities of protein methylase II in pancreatic tissues were examined to test the relationship between protein methylation and pancreatic secretion. The results are as follows. The activity of amylase was slightly increased at the concentration of 10-5M of isoproterenol and norepinephrine. The activities of protein methylase I and II were decreased by isoproterenol and norepinephrine, but the activities of protein methylase III were hardly changed. The cholinergic stimulants acetylcholine and carbachol at a concentration of 10-5M increased the activities of protein methylase I and decreased the activities of protein methylase III compared with control.

키워드

protein methylase isoproterenol norepinephrine propranolol acetylcholine carbachol atropine.