Indoprofen의 합성

• 영문명: Synthesis of Indoprofen
• 발행기관: 대한약학회
• 저자명: 최홍대(Hong Dae Choi) 강병원(Byung Won Kang) 마정주(Jung Joo Ma) 윤호상(Ho Sang Yun)
• 간행물 정보: 『약학회지』제35권 제4호 (1991년), 314~318쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.08.30

영문 초록

A convenient method for the synthesis of indoprofen, which is a potent antiinflammatory agent, was described. Ethyl alpha-(4-aminophenyl)propionate was prepared by nitration of ethyl alpha-phenylpropionate, followed by reduction. Ethyl alpha-[4-(1,3-dioxo-2-iso-indolinyl)phenyl]propionate was obtained from condensation reaction of phthalic anhydride and ethyl alpha-(4-aminophenyl)propionate. Indoprofen was prepared by reduction of ethyl alpha-[3-(1,3-dioxo-2-iso-indolinyl)phenyl]propionate with zinc dust-acetic acid, followed by hydrolysis of the resultant ethyl alpha-[4-(l-oxo-2-iso-indolinyl)phenyl]propionate.

키워드

indoprofen a potent antiinflammatory agent ethyl α-(4-amino-phenyl)propionate ethyl α-phenylpropionate ethyl α-[4-(l,3-dioxo-2-iso-indolinyl)phenyl]propionate condensation reaction ethyl α-[(1-oxo-2-isoindolinyl)phenyl]propionate.