간암세포주 HepG2 2.2.15에서 아만타딘/비페닐디메칠디카르복실레이트 복합제의 항 바이러스 효과

• 영문명: Antiviral Effect of a Combination Therapy of Amantadine/Biphenyl Dimethyl Dicarboxylate in HepG2 2.2.15
• 발행기관: 대한약학회
• 저자명: 주성수(Seong-Soo Joo) 원태준(Tae-Joon Won) 이용진(Young-Jin Lee) 황광우(Kwang-Woo Hwang) 이도익(Do-Ik Lee)
• 간행물 정보: 『약학회지』제49권 제2호 (2005년), 151~155쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.04.30

영문 초록

For decades, the demand for new antiviral strategies, especially in hepatitis, has increased markedly due to its devastating pathogenic outcome, In the present study, we examined the antiviral effect of the combination of amantadine and biphenyl dimethyl dicarboxylate (DDB) in HepG2 2.2.15, which is transfected with HBV DNA. The study demonstrated that the combination not the single treatment may have an anti-HBV effect through a synergism of antiviral, anti-inflammatory and cytoprotective activities in STAT1 α, 6-16 gene, and pro-inflammatory components such as nitric oxide and IL-1β expression. In addition, hepatitis B surface and core gene expression were examined as a final end point for the anti-HBV activities, which was also significantly suppressed comparing to normal control (p<0.01).

키워드

amantadine DDB hepatitis B surface gene hepatitis B core gene HepG2 2.2.15