황기의 지질과산화 억제작용

• 영문명: Antilipidperoxidation activity of Astragalus membranaceus
• 발행기관: 대한약학회
• 저자명: 김은정(Eun-Jung Kim) 양기숙(Ki-Sook Yang)
• 간행물 정보: 『약학회지』제49권 제1호 (2005년), 11~19쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.02.28

영문 초록

The root of Astragalus membranaceus (Leguminosae) has been used in traditional chinese prescriptions for strengthning the superficial resistance, promoting pus discharge and tissue regeneration, diuretis and alleviating edema. Lipid peroxidation has been suggested as a major cause of atherosclerosis, cancer, liver disease, and the aging process. In order to investigate the anti-lipid peroxidation activity, Astragali Radix was extracted with 80% MeOH and fractionated with hexane, CH2Cl2, EtOAc, BuOH and Water. The antilipid peroxidation activities of them were determined by human erythrocyte ghost and CCl4-induced lipid peroxidation. CH2Cl2 and EtOAc fractions, especially, isoflavonoids, 7,2'-dihydroxy-3',4'-dimethoxyisoflavan-7-O-β-D-glucoside and calyco sin-7-O-β-D-glucoside from EtOAc fraction showed anti-lipid peroxidation activities.

키워드

Astragalus membranaceus human erythrocyte ghost anti-lipid peroxidation activities