생쥐의 1-Methyl-4-phenol-1,2,3,6-tetrahydropyridine(MPTP)-유도 신경독청에 대한 대황의 보호효과

• 영문명: Protective Effect of R. palmatum On 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Neurotoxicity in Mice
• 발행기관: 대한약학회
• 저자명: 이형철(Hyung Chul Lee) 김대근(Dae Geun Kim) 조원준(Won Jun Jo) 황석연(Seok Yeon Hwang) 이영구(Young Gu Lee) 김명동(Myung Dong Kim) 전병훈(Byung Hun Jeon)
• 간행물 정보: 『약학회지』제46권 제6호 (2002년), 433~440쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.12.31

영문 초록

The protective efficacy of Rheum palmatum water extract on 1-methyl-4-phenol- 1,2,3,6-tetahydropyridine (MPTP)-induced parkinsonism was studied in C57B76 mice. In order to demonstrate neuroprotective effect of R. palmatum extract, animals were administered intraperitoneally with the water extract (100 or 200 mg/kg/day) for 14 days, and MPTP (10 mg/kg/day) was injected subcutaneously into the mice for the first 6 consecutive days from the beginning 1 hr before R. palmatum extract treatment. All animals were measured the several neurobiochemical markers such as dopamine level and monoamine oxidase B (MAO-B) activity in various regions of brain. The treatment of mice with R. palmatum extract was confirmed recovery effect on MAO-B activity in the cerebellum and the cerebral cortex. R. palmatum Extract was attenuated the MPTF-induced depletion of substantia nigra dopamine. The contents of MDA, a marker of lipid peroxidation, in brain tissues (cerebellum and cerebral cortex mitochondria) were decreased significantly by R. palmatum extract. These results suggest that R. palmatum water extract plays an effective role in attenuating MPTP-induced neurotoxicity in mice. This protective effect of R. palmatum might be estimated the result from the inhibitory activity on monoamine oxidase B and the enhancement of antioxidant activity.

키워드

Rheum palmatum 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine(MPTP) monoamine oxidase B(MAO-B) dopam ine lipid peroxidation C57BL/6 mice.