유향물추출물의 HL-60 혈액암세포에서 세포사멸 유도효과

• 영문명: The water extract of Bowellia carterii induced apotosis in human leukemmia HL-60
• 발행기관: 대한약학회
• 저자명: 박래길(Rae-Kil Park) 오광록(Kwang-Rok Oh) 이광규(Kwang-Gyu Lee) 문연자(Yeun-Ja Mun) 김정훈(Joung-Hoon Kim) 우원홍(Won-Hong Woo)
• 간행물 정보: 『약학회지』제45권 제2호 (2001년), 161~168쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.04.30

영문 초록

The possible mechanism of the antiproliferative and apoptotic effects of Boswellia carterii water extract were studied in HL-60 human leukemia cells. The cytotoxicity of HL-60 cells after the treatment of Boswellia carterii water extract showed dose- and time-dependent manner. The appototic effect of 300 mcg/ml Boswellia carterii water extract was demonstrated by DNA laddering. The activity of capase 3-like protease was markedly increased in HL-60 cells treated with Boswellia carterii water extract. Furthermore, the level of Bcl-2 was time-dependently reduced, whereas Bax protein level was enhanced by Boswellia carterii water extract treatment. In conclusion, our results suggest that apoptotic effect of Boswellia carterii water extract treatment. In conclusion, our results suggest apototic effect of Boswellia carterii water extract may partly mediated through activations of capase-3-activity, and Bax expression, and inhibition of Bcl-2 expression.

키워드

Boswellia carterii water extract apoptosis caspase Bcl-2 Bax