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• 영문명: Analysis of Water-soluble Vitamins in Pharmaceutical Products by Capillary Electrophoresis
• 발행기관: 대한약학회
• 저자명: 이종진(Jong Jin Lee) 문동철(Dong Cheul Moon) 이공주(Kong Joo Lee)
• 간행물 정보: 『약학회지』제38권 제1호 (1994년), 38~45쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.02.28

영문 초록

All analytical method using capillary electrophoresis (CE) was developed for quantitation of water soluble vitamin contents in various vitamin products. The method includes the optimization of separation of 11 water soluble vitamins changing the micellar concentration and pH of running buffer, applied voltage and sample preparation. Best resolution was obtained with 25mM phosphate buffer (pH=8.0) containing 50mM sodium dodecyl sulphate (SDS) as micellar phase. At optimum condition, water soluble vitamins were determined in orange juice and vitamin products such as vitamin C pulvis, vitamin injection, coated multivitamin tablet. The quantitative analysis of water soluble vitamins with CE was suitable for quality control of pharmaceutical products with sound reproducibility.

키워드

capillary electrophoresis SDS micelle water soluble vitamins.