장내 세균에 의한 폰시린의 대사

• 영문명: Metabolism of Poncirin by Intestinal Bacteria
• 발행기관: 대한약학회
• 저자명: 윤황금(W.G. Youn) 현성혜(S. H. Hyun) 김동현(D. H. Kim) 김남재(N. J. Kim) 홍남두(N. D. Hong)
• 간행물 정보: 『약학회지』제37권 제3호 (1993년), 262~269쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.06.30

영문 초록

Poncirin which is one of the flavanone rhamnoglucosides showed anti-inflammatory activity as the major component of fruit of Poncirus trifoliata. Poncirin did not show antiinflammatory effect when it was intraperitoneally administered, but it was very effective when orally administered. Poncirin was not metabolized by blood and liver enzymes but by intestinal bacteria of human and rats. Among the human intestinal bacteria, Streptococcus Y-25 converted poncirin to ponciretin through the poncirenin and Staphylococcus Y-88 converted to ponciretin directly.

키워드

Poncirus trifoliata Poncirin Intestinal bacteria Antiinflammation.