생강추출물의 항위염.항궤양 작용

• 영문명: Antigastritic and Antiulcerative Action of the Extract of Zingiberis Rhizoma
• 발행기관: 대한약학회
• 저자명: 양원경(Won Kyung Yang) 정춘식(Chun Sik Jung) 정기화(Ki Wha Jung) 김재완(Jae Wan Kim) 이은방(Eun Bang Lee)
• 간행물 정보: 『약학회지』제36권 제2호 (1992년), 173~179쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.04.29

영문 초록

The rhizoma of Zingiber officinalehas been used as antiemetic, expectorants, stomachache relieving drugs and digestive accelerators. From the observation of antigastritic action of the methanol extract of the rhizoma, it was fractionated with hexane, chloroform, ethyl acetate and butanol, followed by bioassay on antigastritic and antiulcerative activity. The hexane and the chloroform fraction reduced significantly HCl.ethanol induced gastric lesion at the dose of 370 and 210mg/kg, p.o., respectively. On the gastric ulceration and gastric secretion in pylorus-ligated rats, the hexane fraction decreased the volume of gastric secretion and acid output, and also increased pH at the dose of 370mg/kg, i.d.. It showed considerable curative ratio of acetic acid induced ulcer without inhibition of indomethacin induced gastric lesion. The methanol extract showed low acute toxicity with minimum lethal dose of more than 3000mg/kg, p.o. in mice. In conclusion, Zingiberis rhizoma exhibited antigastric and antiulcerative activity which might be attributable to inhibition of gastric secretion. It is revealed that the active component may be present in the hexane fraction.