학술논문
Usefulness of Pulsatile Flow Aortic Aneurysm Phantoms for Stent-graft Placement
이용수 12
- 영문명
- Usefulness of Pulsatile Flow Aortic Aneurysm Phantoms for Stent-graft Placement
- 발행기관
- 대한방사선과학회(구 대한방사선기술학회)
- 저자명
- Tae-Hyung Kim(김태형) Gi-Young Ko(고기영) Ho-Young Song(송호영) In Kook Park(박인국) Ji Hoon Shin(신지훈) Jin-Oh Lim(임진오) Jin Hyoung Kim(김진형) Eugene K. Choi
- 간행물 정보
- 『방사선기술과학』방사선기술과학 제30권 제3호, 205~212쪽, 전체 8쪽
- 주제분류
- 의약학 > 방사선과학
- 파일형태
- 발행일자
- 2007.09.01
국문 초록
대동맥류 질환에 사용되는 스텐트그라프트의 체외실험을 위한 대동맥류 혈류 팬텀의 유효성과 실현가능성에 대해 평가하고자 한다. 팬텀은 인체의 혈류 조건과 유사한 상황을 재현할 수 있도록 심장부분과 대동맥류 부분으로 구성되었다. 심장부분은 고압력 수중펌프와 솔레노이드 밸브를 사용하여 심장의 대동맥 혈류를 재현하였고, 대동맥류 부분은 지점토를 사용하여 동맥류 모양을 재현하고 그 틀을 투명 실리콘으로 틀을 떠내는 방법으로 제작하였다. 두부분은 실리콘 관으로 연결하였다. 제작된 팬텀에서 밸브의 개폐 시간에 따른 압력(수축기/이완기) 변화를 측정하였으며, 스텐트그라프삽입술 전, 후의 압력변화를 측정하였으며, 통계적 유의성을 알아 보았다. 밸브의 개폐 시간에 따른 압력 변화는 통계적으로 유의한 결과를 보였다(P <0.05). 0.5회/초의 개폐 조건에서는 팬텀의 대동맥 근위부, 대동맥류, 원위부의 압력은 각각 157.80±1.92/130.20±1.92, 159.40±1.14/134.00±2.92, 147.20±1.480/129.60±2.70mmHg이었으며, 1.0회/초의 개폐 조건에서는 161.40±1.34/90.20±1.64, 175.00±1.58/93.00±1.58, 176.80±1.48/90.80±1.92mmHg이었고, 1.5회/초의 개폐 조건에서는 159.40±1.82/127.20±1.48, 166.60±1.67/138.00±1.87, and 161.00±1.22/135.40± 1.67mmHg이었다. 스텐트 그라프삽입술 전, 후의 팬텀의 압력변화는 대동맥부분에서 측정하였으며, 각각 143.60±1.67/90.20±1.64, 147.20±1.92/84.60±1.82, and 137.40±1.52/88.80±1.64mmHg이었다. 결론적으로, 대동맥류 팬텀은 압력의 범위를 다양하게 적용할 수 있고, 팬텀 내에서 시술의 재현이 가능하여 동물실험 전 스텐트그라프트의 유용성을 평가하기 위한 체외실험 기구로 유용할 것으로 기대된다.
영문 초록
To evaluate the feasibility and efficacy of a pulsatile aortic aneurysm phantoms for in-vitro study.
The phantoms consisted of a pulsating motor part(heart part) and an aortic aneurysm part, which mimicked true physiologic conditions. The heart part was created from a high-pressured water pump and a pulsatile flow solenoid valve for the simulation of aortic flow. The aortic aneurysm part was manufactured from paper clay, which was placed inside a acrylic plastic square box, where liquid silicone was poured. After the silicone was formed, the clay was removed, and a silicone tube was used to connect the heart and aneurysm part. We measured the change in pressure as related to the opening time(pulse rate, Kruskal-Wallis method) and pressure before and after the stent-graft implantation(n=5, Wilcoxon"s signed ranks test).
The changes in blood pressures according to pulse rate were all statistically significant(p <0.05). The systolic/diastolic pressures at the proximal aorta, the aortic aneurysm, and the distal aorta of the model were 157.80±1.92/130.20±1.92, 159.40±1.14/134.00±2.92, and 147.20±1.480/129.60±2.70mmHg, respectively, when the pulse rate was 0.5 beat/second. The pressures changed to 161.40±1.34/90.20±1.64, 175.00±1.58/93.00±1.58, and 176.80±1.48/90.80±1.92mmHg, respectively, when the pulse rate was 1.0 beat/second, and 159.40±1.82/127.20±1.48, 166.60±1.67/138.00±1.87, and 161.00±1.22/135.40±1.67 mmHg, respectively, when it was 1.5 beat/second. When pulse rate was set at 1.0 beat/second, the pressures were 143.60±1.67/90.20±1.64, 147.20±1.92/84.60±1.82, and 137.40±1.52/88.80±1.64mmHg after stent-graft implantation. The changes of pressure before and after stent-graft implantation were statistically significant(p <0.05) except the diastolic pressures at the proximal(p =1.00) and distal aorta(p = 0.157).
The aortic aneurysm phantoms seems to be useful for the evaluation of the efficacy of stent-graft before animal or clinical studies because of its easy reproducibility and ability to display a wide range of pressures.
The phantoms consisted of a pulsating motor part(heart part) and an aortic aneurysm part, which mimicked true physiologic conditions. The heart part was created from a high-pressured water pump and a pulsatile flow solenoid valve for the simulation of aortic flow. The aortic aneurysm part was manufactured from paper clay, which was placed inside a acrylic plastic square box, where liquid silicone was poured. After the silicone was formed, the clay was removed, and a silicone tube was used to connect the heart and aneurysm part. We measured the change in pressure as related to the opening time(pulse rate, Kruskal-Wallis method) and pressure before and after the stent-graft implantation(n=5, Wilcoxon"s signed ranks test).
The changes in blood pressures according to pulse rate were all statistically significant(p <0.05). The systolic/diastolic pressures at the proximal aorta, the aortic aneurysm, and the distal aorta of the model were 157.80±1.92/130.20±1.92, 159.40±1.14/134.00±2.92, and 147.20±1.480/129.60±2.70mmHg, respectively, when the pulse rate was 0.5 beat/second. The pressures changed to 161.40±1.34/90.20±1.64, 175.00±1.58/93.00±1.58, and 176.80±1.48/90.80±1.92mmHg, respectively, when the pulse rate was 1.0 beat/second, and 159.40±1.82/127.20±1.48, 166.60±1.67/138.00±1.87, and 161.00±1.22/135.40±1.67 mmHg, respectively, when it was 1.5 beat/second. When pulse rate was set at 1.0 beat/second, the pressures were 143.60±1.67/90.20±1.64, 147.20±1.92/84.60±1.82, and 137.40±1.52/88.80±1.64mmHg after stent-graft implantation. The changes of pressure before and after stent-graft implantation were statistically significant(p <0.05) except the diastolic pressures at the proximal(p =1.00) and distal aorta(p = 0.157).
The aortic aneurysm phantoms seems to be useful for the evaluation of the efficacy of stent-graft before animal or clinical studies because of its easy reproducibility and ability to display a wide range of pressures.
목차
Abstract
Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
Ⅲ. RESULTS
Ⅳ. DISCUSSION
ACKNOWLEDGMENTS
Reference
국문초록
Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
Ⅲ. RESULTS
Ⅳ. DISCUSSION
ACKNOWLEDGMENTS
Reference
국문초록
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