쿠싱증후군을 동반한 비만 환자의 한의치료 후 임상 경과: 다기관 후향적 차트리뷰

• 영문명: Changes in Clinical Parameters after Korean Medicine Treatment in Patients with Obesity and Cushing’s Syndrome: A Multicenter Retrospective Chart Review
• 발행기관: 한방비만학회
• 저자명: 방민우 신수용 김정상 강민휘 이동훈 김준호 김충희 손지영 전성현 강병수
• 간행물 정보: 『대한한방비만학회지』제26권 제1호, 22~32쪽, 전체 11쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2026.06.30

국문 초록

Objectives: This study aimed to evaluate changes in clinical parameters after Korean medicine treatment (KMT) in patients with obesity and a history of Cushing’s syndrome (CS). Methods: This multicenter retrospective chart review included patients with obesity and documented CS who received KMT at eight clinics. Patients with at least two assessments of body composition were included. Treatment consisted of individualized herbal medicine, including Daeat-dan, with low-carbohydrate diet (LCD) guidance. Changes in body composition, hemodynamic variables, glycated hemoglobin A1c (HbA1c), laboratory findings, and adverse events were reviewed. Wilcoxon signed-rank test was used as an exploratory adjunct for pre-post comparisons. Results: Of 20 eligible patients, 9 were included in the final analysis. The mean follow-up period was 154.9±93.3 days. After treatment, body weight, body fat mass, body mass index, and percent body fat decreased. Skeletal muscle mass decreased by 0.27±1.05 kg without statistical significance. HbA1c decreased in both patients with paired measurements. Systolic and diastolic blood pressure showed decreasing trends without significance. Mild adverse events were reported in 3 patients and resolved after treatment adjustment. Conclusions: KMT with LCD was associated with reductions in body weight and fat-related parameters in a small group of patients with obesity and a history of CS. However, endocrine markers of Cushing’s syndrome were not assessed, and adverse events were observed in some patients. Therefore, these findings should be interpreted as preliminary descriptive observations rather than evidence of efficacy or safety for Cushing’s syndrome itself.

목차

서론

대상 및 방법

결과

고찰

결론

Conflict of Interest

References

키워드

Cushing syndrome Obesity Korean traditional medicine Herbal medicine Metabolic syndrome