Phenytoin과 Phenobarbital이 뇌내(腦內) Catecholamine함량(含量)과 혈장(血漿) Corticosterone치(値) 변동(變動)에 미치는 영향(影響)

• 영문명: Influence of Phenytoin and Phenobarbital on the Changes of Brain Norepinephrine Content and Plasma Corticosterone Level in Mice
• 발행기관: 대한약리학회
• 저자명: 김남헌(Nam Heon Kim) 천연숙(Yun Sook Cheon)
• 간행물 정보: 『대한약리학잡지』제18권 제2호, 51~58쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1982.12.31

영문 초록

In this paper, the influence of phenytoin and phenobarbical on the changes of brain norepinephrine(NE) content, plasma corticosterone and blood sugar level in mice were studied. The results obtained were summarized as follows: 1) Phenytoin(50 mg/kg) increased the brain NE content but phenobarbital(50 mg/kg) did not affect. The increase of the brain NE content induced phenytoin was potentiated by phenobarbital pretreatment. 2) Phenytoin(25 mg/kg, 50 mg/kg) markedly increased the level of plasma corticosterone but phenobarbital did not affect. The increase of the plasma corticosterone induced by phenytoin was inhibited by phenobarbital pretreatment. 3) Phenytoin(50 mg/kg) markedly increased the blood sugar level but phenobarbital did not affect. The increase of the blood sugar induced by phenytoin was not affected by phenobarbital pretreatment.