The Gut-Brain Axis in Parkinson’s Disease: Probiotic Interventions and Mechanistic Insights

• 발행기관: 한국유산균프로바이오틱스학회
• 저자명: Muhammad Adeel Hasnain Hafiza Hira Bashir Gi-Seong Moon
• 간행물 정보: 『Current Topics in Lactic Acid Bacteria and Probiotics』11권 2호, 41~49쪽, 전체 9쪽
• 주제분류: 농수해양 > 식품과학
• 파일형태: PDF
• 발행일자: 2025.12.30

국문 초록

Parkinson's disease (PD), a progressive neurodegenerative disease, is characterized by various motor and non-motor symptoms like tremors and rigidity, cognitive impairment, and gastrointestinal problems. Recent research indicates that gut dysbiosis plays a crucial part in the pathophysiology of PD, connecting microbial imbalances to dopaminergic neuronal loss, α-synuclein aggregation, and neuroinflammation via the gut-brain axis. Probiotics have shown promise as therapeutic agents in PD since they can improve both motor and non-motor symptoms of PD, lower inflammation, and restore gut microbial balance. The effectiveness of specific probiotic strains in reducing the progression of disease symptoms is demonstrated by recent research. This review gives a comprehensive overview of current research about role of gut dysbiosis in PD development and progression and provides insights into the potential of probiotics in management of PD.

목차

Introduction

Gut Microbiota and Gut-Brain Axis

Gut Dysbiosis and PD

Probiotics as a Therapeutic Strategy for PD Amelioration

Gut Health Improvement

Modulation of Immunity and Inflammation

Neuronal Protection and α-Synuclein Modulation

Microbial and Microbial Metabolite-Driven Mechanisms

Current Gaps and Future Directions

Acknowledgements

References

키워드

Parkinson’s disease gut-brain axis neurodegenerative disorder gut dysbiosis probiotics