C-뉴크레오사이드의 화학합성

• 영문명: The Chemical Syntheses of C-Nucleosides
• 발행기관: 대한약학회
• 저자명: 천문우(Moon Woo Chun) 김중협(Joong Hyup Kim) 와따나베 에이 쿄오이치(Kyoichi A. Watanabe)
• 간행물 정보: 『약학회지』제35권 제6호 (1991년), 530~554쪽, 전체 25쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.12.30

영문 초록

The synthetic methodologies for the preparation of C-nucleosides are divided into four categories, and each category is discussed in details. The chemical reactions which lead to other C-nucleosides from preformed the natural product pseudouridine are described first, followed by synthesis of C-nucleosides by condensation of pre-formed heterocyclic base with sugar, and by construction of heterocyclic base from a carbohydrate intermediate that bear functional carbon fragment at the anomeric position. Finally, methods of total synthesis of C-nucleosides from carbohydrate and achiral starting materials are presented.

키워드

C-nucleosides total synthesis interconversion