Piperazinyl Quinolone계 유도체의 합성 및 항균작용

• 영문명: Synthesis and Antimicrobial Activities of Piperazinyl Quinolone Derivatives
• 발행기관: 대한약학회
• 저자명: 임철부(Chul Bu Yim) 이영운(Young Woon Lee) 최수항(Su Hang Choi) 염정록(Jeong Rok Youm) 허인회(In Hoi Huh)
• 간행물 정보: 『약학회지』제35권 제6호 (1991년), 515~521쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.12.30

영문 초록

A number of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-substitutedcarbamyl-1-piperazinyl) quinoline [or 1,8-naphthyridine]-3-carboxylic acid and their pivaloyloxymethyl esters were prepared. The compounds synthesized were evaluated for antibacterial activity in vitro against Escherichia coli, Bacillus subtilis, Proteus vulgaiis, Klebsiella pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa. Among those 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methylcarbamyl-l-piperazinyl) quinoline-3-carboxylic acid [1] and 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methylcarbamyl-1-piperazinyl)1,8-naphthyridine-3-carboxylic acid [6] showed the most potent in vitro antibacterial activity.

키워드

Piperazinyl quinolone derivatives antibacterial activity.