관류 흰쥐 간에서 1,2-Dioctanoyl-sn-Glycerol에 의한 글루코오스의 유리작용

• 영문명: Glucose Release Induced by 1,2-Dioctanoyl-sn-Glycerol in Perfused Rat Liver
• 발행기관: 대한약학회
• 저자명: 황영은(Young Eun Hwang) 문은순(Eun Soon Moon) 김미영(Mie Young Kim)
• 간행물 정보: 『약학회지』제35권 제6호 (1991년), 509~514쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.12.30

영문 초록

The effect of diacylglycerol on glucose release was studied by using 1,2-dioctanoyl- sn-glycerol (diC8), a cell permeable diacylglycerol, in perfused rat liver. The glucose release was increased by diC8(50 mcM), and the effect was depended on calcium ions. The increment of glucose release by diC8(50 mcM) was inhibited by indomethacin (50 mcM); the amount of glucose release was almost the same with that of control group. Arachidonic acid(200 mcM) also increased glucose release and the release was inhibited by indomethacin. There was no synergistic effect on glucose release by the combination of diC8(50 mcM) and phenylephrine(10 mcM).

키워드

Diacylglycerol perfused rat liver glucose release cyclooxygenase.