Physics of Nerves and Excitatory Membranes

Thomas Heimburg 지음

Wiley-Blackwell 2025년 11월 28일 출간

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Ground-breaking reference explaining the biological properties of nerve cell membranes from a unifying physical perspective Without neglecting the known theories of nerve impulse propagation, Physics of Nerves and Excitatory Membranes focuses on the less known features of nerve cell membranes, such as their mechanical, caloric and optical properties. Based on these properties, the author then develops an electromechanical theory of pulse propagation, offering the most plausible explanation yet for some unresolved questions regarding the effects observed during general anesthesia. Physics of Nerves and Excitatory Membranes is didactically written and includes information on: The structure and electrical properties of nerves, dimensions and mechanical properties of the nerve pulse, and optical changes during the action potential Cable theory, voltage gating, the Hodgkin-Huxley model, and protein ion channels Membrane structure and melting, phase behavior, domains, and rafts, and the influence of pressure, voltage, drugs, proteins, pH, and ionic strength Heat capacity, sound propagation, relaxation timescales, and capacitance and capacitive susceptibility The emergence of solitary nerve pulses in a biological membrane under physiological conditions Voltage-gated and mechanosensitive lipid channels, temperature sensing, and selectivity of lipid channels Physics of Nerves and Excitatory Membranes is of prime interest for biophysicists studying biomembranes as well as for neurobiologists and clinical researchers studying anesthesia. Its accessible style makes it very well suited for teaching the subjects that it covers.

목차

Part I: INTRODUCTION I.1 Early Nerve Studies I.2 The early period of electrophysiology I.3 The Hodgkin-Huxley model and beyond I.4 Another line of thought I.5 Scope of this book Part II: THERMODYNAMICS II.1 Fundamental laws in thermodynamics II.2 Some statistical Thermodynamics II.3 Entropy II.4 The fluctuation relations Part III: PROPERTIES OF NERVES III.1 Structure of nerves III.2 Electrical properties of nerves III.3 The dimensions of the nerve pulse III.4 Mechanical properties of the nerve pulse III.5 Optical changes during the action potential III.6 Heat production and temperature changes during the nerve pulse III.7 Magnetic fields generated during the action potential III.8 Collisions of nerve pulses Part IV: BASIC PRINCIPLES OF ELECTROPHYSIOLOGY IV.1 Some historical considerations IV.2 Cable theory IV.3 Voltage Gating IV.4 The Hodgkin-Huxley model IV.5 Implications of the Hodgkin-Huxley model Part V: PROPERTIES OF ARTIFICIAL AND BIOLOGICAL MEMBRANES V.1 Membrane Structure V.2 Membrane Melting V.3 Phase behavior, domains and rafts V.4 Influence of hydrostatic pressure and lateral pressure V.5 Curvature V.6 Influence of pH and ionic strength V.7 Influence of Voltage V.8 Influence of Drugs and proteins Part VI: FLUCTUATIONS AND SUSCEPTIBILITIES VI.1 Entropy and fluctuations VI.2 Heat capacity VI.3 Relation between enthalpy, volume and area changes VI.4 Transitions and elastic constants VI.5 Sound propagation VI.6 Capacitance and capacitive susceptibility VI.7 Relaxation timescales Part VII: THE SOLITON THEORY VII.1 Hydrodynamics and sound propagation VII.2 Sound velocity in nerve membranes VII.3 The frequency dependence of the sound velocity VII.4 The nerve pulse as an electromechanical soliton VII.5 Nerve contraction and pulse trains VII.6 Excitation of solitons V

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저자(글) Thomas Heimburg