Drug Metabolism and Pharmacokinetics

Liang Shen 지음

Wiley 2025년 06월 03일 출간

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Practical, state-of-the-art pharmacokinetic research methods, ideas, advancements, applications, and strategies Drawing on a wealth of extensive practical experience and theoretical research, Drug Metabolism and Pharmacokinetics encapsulates the most recent advancements and illustrative applications in the field. Sixty-eight relatively independent yet interconnected articles are included, each offering a unique perspective and providing in-depth interpretation. Readers can either read systematically or select specific topics of interest from the table of contents. Basic concepts, frontier advancements, DMPK research strategies, and technical methods are covered for novel drug modalities and therapeutics in different disease areas. The book encompasses a wide range of application and validation cases for DMPK research, including studies in in vitro ADME, in vivo pharmacokinetics, metabolite profiling and identification, radiolabeled ADME, and bioanalysis. Case studies showing the application of topics covered are included throughout, along with valuable insights into problem-solving and critical thinking. Written by a team of scientists specializing in DMPK research from the DMPK Department of WuXi AppTec, Drug Metabolism and Pharmacokinetics discusses sample topics including: ADME properties, metabolite identification, and bioanalytical strategies for oligonucleotide drugsStrategies and challenges in the determination of drug-to-antibody ratio (DAR) values of antibody-drug conjugates (ADCs)Breaking barriers in CNS drug development with intrathecal and intracerebroventricular administrationApplication and detection techniques of biomarkers in drug developmentFlux dialysis method for assessing plasma protein binding of high protein-binding drugs Drug Metabolism and Pharmacokinetics is an essential forward-thinking reference on the subject for pharmacy student

목차

About the Editors ix Preface xi Acknowledgments xiii Section I Novel Drug Modalities: Advancements and Their Pharmacokinetic Strategies 1 1 Proteolysis-Targeting Chimeras (PROTACs) 3 1.1 An Overview of PROTAC Technology and Drug Metabolism and Pharmacokinetic (DMPK) Research Strategies 3 1.2 Strategies to Improve the Oral Bioavailability of PROTACs 9 1.3 Research on PROTAC Metabolism: Strategies and Main Approaches 17 1.4 Metabolic Characteristics and Research Strategies for Metabolite Identification of PROTACs 23 1.5 Evaluation of Drug-Drug Interactions of PROTACs with Efflux Transporters 40 1.6 PROTAC Bioanalysis: Challenges and Strategies 44 2 Antibody Drug Conjugates (ADCs) 49 2.1 General Considerations for Pharmacokinetic Studies of ADCs 49 2.2 Application of Integrated Bioanalysis in ADC DMPK Studies 53 2.3 Study Models and Bioanalysis Methods for the Payload-Related Metabolite Identification Studies of ADCs 62 2.4 Strategies and Challenges in the Determination of Drug-to-Antibody Ratio (DAR) Values for ADCs 67 2.5 In Vitro Stability of ADCs in Blood Matrices 78 2.6 Application of Radiolabeling Techniques in ADC Pharmacokinetic Studies 86 3 Peptide Drug Conjugates (PDCs) 95 3.1 Introduction to PDCs and DMPK Research Strategies 95 3.2 Targeted Release Principle and Metabolite Identification Studies of PDCs 102 4 Peptide Drugs 115 4.1 Development, Characteristics, and Pharmacokinetic Research Strategies of Peptide Drugs 115 4.2 Metabolic Characteristics and Optimization Strategies of Peptide Drugs 123 4.3 Insights into ADME Studies of 37 Approved Therapeutic Peptides: Strategies and Radiolabeling Considerations 132 4.4 Challenges and Strategies in the Bioanalysis of Peptide Drugs 138 5 Oligonucleotide (OLIGO) Drugs 147 5.1 Oligonucl

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저자(글) Liang Shen