Mineralizing Vesicles

Massimo Bottini , Ana Paula Ramos 지음

Elsevier 2023년 11월 30일 출간

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Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease presents the state-of-the art in the properties of mineralizing EVs and their potential clinical applications. The first chapter presents foundational biochemical and biological aspects of EVs. Next, the title coves the role of EVs in bone ossification and in cardiovascular and cartilage-related diseases. Considering the unique ability of this class of EVs to form apatite minerals assigned to their special biochemical machinery, three chapters of the book then focus on the enzymes catalysing the inorganic phosphate and calcium turn-over and the dynamic properties of the vesicles’ peripheral proteins. Chapters describe the role of inorganic phosphate and calcium ions and of autophagy on the biogenesis and function of mineralizing EVs. Recent studies show that the lumen of mineralizing EVs is partially filled with miRNA, and a chapter therefore considers research on the possible function of these vesicles as signalosomes. The final five chapters of the book describe practical aspects of working with mineralizing EVs, including their purification, proteomic and biophysical analyses, the use of biomimetic models and mineralizing EVs in regenerative medicine. This title presents, for the first time, a comprehensive account of mineralizing EVs and their potential clinical applications. It will be invaluable to researchers in the field. • Covers all aspects of mineralizing EVs, from their composition to their function in physiological   and pathological processes, and their clinical potential• Presents mineralizing EVs systematically using clear accessible language• Describes practical aspects of working with mineralizing EVs• Integrates an account of the biochemistry and biophysics of vesicles with their functions• Takes a multidisciplinary perspective, offering an exhaustive and cutting-edge account of mineralizing EV

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ContributorsShort biographies of the contributorsPreface1. General aspects of extracellular vesicles in bone formation and remodeling Antonio Maurizi and Anna Teti1. Introduction 2. Communications between bone cells 3. Extracellular vesicles 4. Bone cell overview 5. Bone marrow cells interacting with skeletal cells 6. Extracellular vesicle trafficking in the bone microenvironment 7. Extracellular vesicles in fracture healing 8. Extracellular vesicles and bone cancer 9. Medical applications 10. Conclusions List of abbreviations Acknowledgments References 2. Physiological biomineralization. The properties and role of matrix vesicles in skeletal and dental calcifications René Buchet, Saida Mebarek, Slawomir Pikula, Agnieszka Strzelecka-Kiliszek, David Magne, Leticia Fernanda Duffles, Thaise Mayumi Taira, Massimo Bottini, Pietro Ciancaglini, José Luis Millán and Sandra Yasuyo Fukada1. Introduction 2. Biomineralization in teeth 3. Biomineralization in bones 4. Determinants of mineralization support the functions of matrix vesicles 5. Conclusions List of abbreviations Acknowledgments References 3. Pathological biomineralization. Part I: mineralizing extracellular vesicles in cardiovascular diseases Rene Buchet, Slawomir Pikula, Agnieszka Strzelecka-Kiliszek, Massimo Bottini, Ana Paula Ramos, Pietro Ciancaglini, Jose Luis Millan and Saida Mebarek1. Introduction 2. Extracellular vesicles: origin and classification 3. Extracellular vesicles related to cardiovascular diseases 4. Extracellular vesicles: biomarkers of cardiovascular diseases 5. Extracellular vesicles as drug delivery vehicles in cardiovascular disease6. ConclusionsList of abbreviations Acknowledgments References4. Pathologic biomineralization: part II: mineralizing extracellular vesicles in osteoarthritis Ann

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저자(글) Massimo Bottini

저자(글) Ana Paula Ramos