Patient Centric Blood Sampling and Quantitative Analysis

Neil Spooner , Emily Ehrenfeld , Joe Siple , Mike S. Lee 지음

Wiley 2023년 10월 16일 출간

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PATIENT CENTRIC BLOOD SAMPLING AND QUANTITATIVE ANALYSIS Authoritative resource providing a complete overview of patient centric blood sampling, as well as its benefits and challenges Patient Centric Blood Sampling and Quantitative Analysis focuses on the growing interest in alternative means to standard phlebotomy and analytical workflows for the collection and analysis of high-quality human biological samples for the quantitative determination of circulating drugs, their metabolites, and endogenous substances for clinical trials, routine healthcare and neonatal screening. The book clearly explains the benefits and constraints of having patients collect small volumes of blood in locations outside of a clinic (e.g at home), including: patient convenience; less invasive procedures; increased frequency of sampling; applicability to collecting samples from the young, elderly, and those in remote locations; greater frequency; and lower cost per sample. Readers will learn about approaches for successfully implementing patient centric sampling workflows in a number of scenarios, including the clinical setting and in the analytical laboratory. Edited by four recognized experts in this field, with additional specialists in the discipline enlisted to write the component chapters, enabling greater depth and detail to be added and further raising the scientific standing of the publication, Patient Centric Blood Sampling and Quantitative Analysis includes information on: Basics of patient centric blood sampling and techniques and approaches that are available and in development for the collection and analysis of the samples Science behind patient centric blood sampling and its implications regarding human healthcare and wellbeing Application areas of patient centric sampling, including drug development, clinical chemistry/pathology, therapeutic drug monitoring, and more Practical approaches to successful im

목차

List of Contributors xiii Foreword xvii Preface xix 1 Patient Centric Healthcare What’s Stopping Us? 1 Jenny Royle and Rachel Jones 1.1 The Evolution of Future Health Systems 1 1.2 Exploring the Barriers to Home Sampling 3 1.2.1 Barrier One—The Discord Between Innovation and Practice 4 1.2.2 Barrier Two—Ethical and Operational Considerations 5 1.2.3 Barrier Three—Where Does the Liability Sit? 7 1.2.4 Barrier Four—Addressing the Technology Challenge 8 1.2.5 Barrier Five—The Human Touch 9 1.2.6 Barrier Six—Trust in Data Security 10 1.2.7 Barrier 7—Adherence to Service Change 11 1.3 Conclusion: The Changing Role of Home Sampling 12 References 13 2 Tips for Successful Quantitative Assay Development Using Mitra Blood Sampling with Volumetric Absorptive Microsampling 17 James Rudge 2.1 What is Volumetric Absorptive Microsampling? 17 2.2 Tip 1—Ensure the Use of a Correct Sampling Procedure to Prevent Volume-Related Biases 18 2.3 Tip 2—Working with Wet Whole Blood 19 2.3.1 Is Your Choice of Assay Biologically Relevant in Blood? 19 2.3.2 Working with Blood as a Matrix 20 2.3.3 Allowing Analytes to Equilibrate Ex Vivo 21 2.3.4 Bridging Between Venous Capillary Blood and the Role of Anticoagulants 22 2.4 Tip 3—Working with Dried Whole Blood 24 2.4.1 Dried Blood Spot Cards 24 2.4.2 Volumetric Hematocrit Bias—Blood Viscosity 25 2.4.3 Dried Blood is a Complicated Matrix 26 2.4.4 Working with “Aged” Blood 26 2.4.5 Temporal Extraction Bias or Degradation? 27 2.5 Tip 4—Optimizing Extraction Efficiencies from VAMS 29 2.5.1 Measuring Percentage Recovery from Mitra Samplers 30 2.5.2 Extraction Conditions—Where to Start 31 2.5.2.1 Consulting the Literature and Matching Physicochemical Properties 31 2.5.2.2 Adapting

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작가정보

저자(글) Neil Spooner

저자(글) Emily Ehrenfeld

저자(글) Joe Siple

저자(글) Mike S. Lee