Polymer-Drug Conjugates

Jitender Madan , Ashish Baldi , Monika Chaudhary , Neetu Chopra 지음

Elsevier 2023년 06월 30일 출간

작품소개

책소개

Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of ‘Linker Chemistry’ in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding. The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits. Covers mechanism, protocol and therapeutic significance of Polymer-Drug Conjugates Outlines updated methods and techniques to enumerate conjugation with related case studies Includes comprehensive compilation of marketed and clinical trial drugs conjugated with polymers or linkers

목차

1. Drug Delivery: The conceptual perspectives and therapeutic applications 2. Rational design of linkers in polymer drug conjugates3. Exploration of polymers in drug delivery: The structural and functional considerations4. Chemistry of conjugation in drug delivery: The prospects of biodegradable and non-biodegradable bonds5. Polymer-drug conjugation using ester and orthoester bond: Mechanism, protocols and applications6. Polymer-drug linking through amide bonds: The chemistry and applications in drug delivery 7. Drug-Polymer conjugate tailoring by disulfide linkage and its exploration in drug distribution8. Thioether linkage Chemistry: Perspectives and prospects in therapeutic designing9. Drug targeting to cancer cells through stimuli responsive imine bonds: Fascinating aspects of site specificity 10. Carbamate-drug conjugates in drug delivery: Structural and mechanistic considerations11. Bonding through phosphodiester moiety: Its implications in pharmaceutical modifications 12. Enzymatically degradable linkers13. Dendrimer-Drug conjugates14. Antibody-Drug conjugates15. Polymer-Drug Conjugates in Clinical Trials: Challenges, Opportunities and Future prospects

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작가정보

저자(글) Jitender Madan

저자(글) Ashish Baldi

저자(글) Monika Chaudhary

저자(글) Neetu Chopra