Macrocyclic Polyamines

Xiaoqi Yu , Ji Zhang 지음

Wiley-VCH 2017년 10월 30일 출간

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The first comprehensive book focusing on synthesis and applications of macrocyclic polyamines and their derivatives Macrocyclic polyamines are a class of widely used important compounds. This is the first book that systematically summarizes the synthesis and applications of macrocyclic polyamines and their analogues, including the properties and synthetic methods of macrocyclic polyamines, chemical nucleases based on macrocyclic polyamines, the derivatives of macrocyclic polyamines as nano-vector materials, macrocyclic polyamines derivatives for bio-imaging, chemical sensors based on macrocyclic polyamines, and other applications of macrocyclic polyamines. Macrocyclic Polyamines: Synthesis and Applications includes most of the studies involving macrocyclic polyamines and their derivatives, and may be used as a reference for the researchers in related fields. It offers in-depth coverage of cyclization modes; special procedures for tetraza macrocyclic compounds; diacids-diamines condensation; oxidative DNA cleaving by macrocyclic polyamines; lipids with cationic MPA headgroups; the derivatives of DOTA, DO3A, and PCTA; receptors for anions; sensors for bioactive molecules; macrocyclic polyamines for solvent extraction and membrane transport of amino acids and their derivatives, electrophoretic separation, and open-tubular CEC; and much more. The first book that systematically summarizes the chemistry of macrocyclic polyamines and their derivatives in terms of synthetic methods for their preparation, functionalization, and application in the main fields of chemical sensors, chemical nucleases, drug-delivery, bio-imaging and vector materials Provides a comprehensive reference for the researchers working on macrocyclic polyamines Offers train of thought in related research fields such as organic chemistry, coordination chemistry, analytical chemistry, supramolecular chemistry, biomaterials, etc. <

목차

Preface ix 1 Introduction 1 1.1 Classification of Macrocyclic Polyamines 1 1.1.1 Aliphatic Macrocyclic Polyamines 1 1.1.2 Aromatic-ContainingMacrocyclic Polyamines 1 1.1.3 Macrocyclic Polyimines 2 1.1.4 Macrocyclic Polyamides 2 1.1.5 Cryptands 2 1.2 Properties of Macrocyclic Polyamines 3 1.2.1 Acid Base Properties 3 1.2.2 Coordination Property 3 1.3 Applications of Macrocyclic Polyamines 4 References 5 2 SyntheticMethods for Macrocyclic Polyamines 7 2.1 Ring-Closure Modes 7 2.1.1 Intramolecular Cyclization 7 2.1.2 1 + 1 Cyclization 7 2.1.3 2 + 2 Cyclization 8 2.1.4 Other Cyclization Modes 8 2.2 The Synthesis of Saturated Macrocyclic Polyamines 9 2.2.1 Ring Closure Using Sulfonamides 9 2.2.2 The Removal of Tosyl Protecting Groups 11 2.2.3 The Use of Easily Removable Protecting Groups 12 2.2.4 Special Procedures for TetraazaMacrocyclic Compounds 13 2.3 Aromatic Subunit-Containing Polyazamacrocycles 14 2.3.1 Alkylation of Sulfonamide Salts with Dihalomethyl Arenes 15 2.3.2 Metal-Catalyzed N-arylation 16 2.4 Macrocyclic Polyimines (Schiff Bases) 18 2.4.1 Metal Template Reactions 18 2.4.1.1 Macrocyclic Schiff Bases without Aromatic Units 20 2.4.1.2 Macrocyclic Schiff Bases Containing Aromatic Units 21 2.4.2 Template-Free Cyclization 22 2.4.2.1 Condensation of Carbonyls with Aliphatic Diamines 23 2.4.2.2 Condensation of Carbonyls with Aromatic Diamines 25 2.5 Macrocyclic Amides 26 2.5.1 The Crab-Like Cyclization 26 2.5.2 Diacid-Diamine Condensation 29 2.6 Cryptands 33 2.6.1 Coupling of the Preformed Macrocycles 33 2.6.2 Direct Organic Synthesis 35 2.6.3 Spherical Cryptands 37 References 39 3 Chemical Nucleases Based on Macrocyclic Polyamines 45 3.1 Hydr

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저자(글) Xiaoqi Yu

Xiao-Qi Yu, PhD, is Changjiang Chair professor and Dean of College of Chemistry, Sichuan University. He has received several awards, including the Distinguished Young Scholars Awarded (2007, National Science Foundation of China). Ji Zhang, PhD is a professor in College of Chemistry, Sichuan University, China. His research focuses on nano-biomaterials, i.e. design, synthesis and establishment of novel non-viral gene and drug delivery systems and relative structure-activity relationship (SAR) studies.

저자(글) Ji Zhang