Reactions and Syntheses

Lutz F. Tietze , Theophil Eicher , Ulf Diederichsen , Andreas Speicher , Nina Schützenmeister 지음

Wiley-VCH 2015년 02월 23일 출간

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The second edition of this classic text book has been completely revised, updated, and extended to include chapters on biomimetic amination reactions, Wacker oxidation, and useful domino reactions.The first-class author team with long-standing experience in practical courses on organic chemistry covers a multitude of preparative procedures of reaction types and compound classes indispensable in modern organic synthesis. Throughout, the experiments are accompanied by the theoretical and mechanistic fundamentals, while the clearly structured sub-chapters provide concise background information, retrosynthetic analysis, information on isolation and purification, analytical data as well as current literature citations. Finally, in each case the synthesis is labeled with one of three levels of difficulty.An indispensable manual for students and lecturers in chemistry, organic chemists, as well as lab technicians and chemists in the pharmaceutical and agrochemical industries.

목차

1 C-C BOND FORMATION 1.1 Nucleophilic Addition to Aldehydes, Ketones, Carboxylic Acid Derivatives (Esters, Anhydrides) and alpha,beta-Unsaturated Carbonyl Compounds; Carbonyl Olefination 1.2 Alkylation of Aldehydes/Ketones, Carboxylic Acids, and beta-Dicarbonyl Compounds 1.3 Reactions of the Aldol and Mannich Type 1.4 Electrophilic and Nucleophilic Acylation 1.5 Reactions of Alkenes via Carbenium Ions 1.6 Transition-Metal-Catalyzed Reactions 1.7 Pericyclic Reactions 1.8 Radical Reactions 2 OXIDATION AND REDUCTION 2.1 Epoxidation of C=C Bonds 2.2 Dihydroxylation of C=C Bonds 2.3 Oxidation of Alcohols to Carbonyl Compounds 2.4 Enantioselective Reduction of Ketones 2.5 Biomimetic Reductive Amination *NEW* 2.6 Enantioselective Wacker Oxidation for the Synthesis Of Chromans *NEW* 3 HETEROCYCLIC COMPOUNDS 3.1 Three- and Four-Membered Heterocycles 3.2 Five-Membered Heterocycles 3.3 Six-Membered Heterocycles 3.4 Condensed Heterocycles 3.5 Other Heterocyclic Systems; Heterocyclic Dyes 4 SELECTED NATURAL PRODUCTS 4.1 Isoprenoids 4.2 Carbohydrates 4.3 Amino Acids and Peptides 4.4 Nucleotides and Oligonucleotides 5 DOMINO REACTIONS *NEW* 5.1 Domino Reactions in Synthetic Methodology 5.2 Domino Reactions in The Synthesis of Alkaloids 5.3 Domino Reactions in The Synthesis of Isoprenoids 5.4 Domino Reactions for The Synthesis of Chromans And Dioxins 5.5 Domino Reactions in The Synthesis of Chiroptical Switches 6 INDEX OF REACTIONS 7 INDEX OF PRODUCTS 8 SUBJECT INDEX

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저자(글) Lutz F. Tietze

Lutz F. Tietze studied chemistry at the universities of Freiburg and Kiel, Germany, and obtained his doctorate under the supervision of Prof. B. Franck in 1968 in Kiel. He then worked as a research associate with Prof. G. B chi at MIT, Cambridge, USA, as well as with Prof. A. Battersby in Cambridge, UK. Since 1978 he has been Professor and Head of the Institute of Organic and Biomolecular Chemistry at the Georg-August-University in G ttingen, Germany. He has received many prizes, e.g. the highly prestigious Emil Fischer Medal of the German Chemical Society and has been awarded in 2012 with the position of a Distinguished Research Professor. His research focuses on the development of efficient and selective synthetic methods, combinatorial chemistry, the total synthesis of natural products and the design of new selective anticancer agents. He has over 460 papers, 34 patents and four books to his name. Theophil Eicher studied chemistry at the University of Heidelberg, Germany, and obtaind his Ph.D. under Georg Wittig in 1960. After postdoctoral work at Columbia University, New York, USA, in the laboratories of Ronald Breslow, he habilitated 1967 at the University of W rzburg, Germany, under Siegfried H nig. In 1974 he was appointed as Associate Professor at the University of Hamburg, in 1976 as Full Professor of Organic Chemistry at the University of Dortmund, Germany. Since 1982, he worked as Full Professor at the University of the Saarland, Germany, and was retired in 2000. His research interests concerned the synthetic chemistry of cyclopropenones and triafulvenes, as well as natural product synthesis in the field of bryophyte constituents. He is co-author of several books. Jointly with L. F. Tietze, he was awarded the literature prize of the "Fonds der chemischen Industrie". He is Dr. h. c. and Prof. a. h. of the Facultad de Quimica of the Universidad de la Republica, Montevideo/Uruguay. Ulf Diederichsen studied Chemistry in Freiburg, Ger

저자(글) Theophil Eicher

저자(글) Ulf Diederichsen

저자(글) Andreas Speicher

저자(글) Nina Schützenmeister