Applied Biocatalysis

Andreas Liese , Lutz Hilterhaus , Ulrich Kettling , Garabed Antranikian 지음

Wiley-VCH 2016년 06월 14일 출간

작품소개

책소개

This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.

목차

FERMENTATION & DOWNSTREAM PROCESSING TECHNOLOGIES Process development tools for fermentations under extreme conditions (ProTool) Development of fully automated integrated bioprocesses in an industrial compatible pilot plant for the production of heterologous enzymes in yeast Application of tailor made porous adsorbents in enzymatic processes In-situ video microscopy for investigation and optimization of protein crystallization in downstream processing Innovative plasma technology for enzyme immobilization New membrane adsorber technology for downstream processing in enzyme production BIOCATALYSIS & BIOTECHNOLOGICAL PRODUCTION PROZESSES Biocatalysis in high viscous media COMPASITES: Computer assisted analysis of active centers in proteins Kongeneric lipases with improved catalytic activity and substrate accessibility Biocatalytic exploitation of flavonoids New Bacillus expression systems First SeSaM-mutagenesis kit for evolutionary biocatalyst design Development of a probiotic preserving agent for industrial applications Development of a biotechnological production process for non-natural cyclopeptides - BioPEP Biocatalytic exploitation of flavor enhancing aroma compounds STABLE ENZYMES Enzymatic oxidation systems food and technical applications Preparation of new perhydrolases: Simultaneous enhancement of specific activity of perhydrolases and reduction of hydrolysis activity Nucleases and proteases exhibiting improved properties for molecular preanalytics Stable enzymes for the conversion of high value and uncommon substrates

작가정보

저자(글) Andreas Liese

Andreas Liese is Professor for Technical Biocatalysis at the Hamburg University of Technology. He studied chemistry at the University of Bonn, Germany and carried out his doctoral research at the Research Center J lich, Germany. From 1998 to 2003 he was assistant professor at the University of Bonn and at the same time head of the Enzyme Group within the Institute of Biotechnology II (Prof. Dr. C. Wandrey), Research Center J lich. During a sabbatical in 2000 at Pfizer Global Research & Development, San Diego, USA, he there initiated a R&D group on biocatalysis. From 2003 to 2004 he worked as associate professor at the University of M nster, soon receiving a full professorship for Technical Biocatalysis 2004 at the Hamburg University of Technology (TUHH) as the director of the Institute of Technical Biocatalysis. In 2003 Liese received the Award of Up-and-Coming Teacher in Higher Education in the field of biotechnology (DECHEMA, Germany). He is elected member of the steering committee "Biotechnology" of the DECHEMA e.V. since 2005 and elected member of the steering committee of the German Catalysis Society since 2009 Dr. Lutz Hilterhaus is Junior Group Leader at the Institute of Technical Biocatalysis at the TUHH in Hamburg, Germany. He carried out his studies of chemistry at the University M nster before moving to Hamburg. Having obtained his PhD from TUHH in the working group of Prof. Liese in 2008, he spent one year with Prof. Bornscheuer at the University Greifswald before taking up the possibility to start his habilitation at TUHH. Dr. Hilterhaus has authored over 30 scientific publications and has received the "Karl-Heinz-Ditze Preis f r besondere Leistungen in den Ingenieurwissenschaften" in 2008. Dr. Ulrich Kettling is Head of R&D at the Clariant Biotech & Renewables Center, M nchen. Before he worked at S d-Chemie AG until S d-Chemie was acquired by Clariant in 2011. Before joining S d-Chemie, he was co-founder and Chief Scientific Officer o

저자(글) Lutz Hilterhaus

저자(글) Ulrich Kettling

저자(글) Garabed Antranikian