Biochemistry of Signal Transduction and Regulation

Gerhard Krauss 지음

Wiley-VCH 2014년 02월 14일 출간

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Originally based on a graduate course taught by the author, this true classic has once again been extensively updated to incorporate key new findings in biological signaling. With over half of the content re-written, plus 70 brand new and 50 revised figures, this is the most up-to-date textbook on signaling available anywhere.Thanks to its clear structure, hundreds of illustrative drawings, as well as chapter introductions and newly added study questions, this text excels as a companion for a course on biological signaling, and equally as an introductory reference to the field for students and researchers. Generations of students and junior researchers have relied on quot;the Kraussquot; to find their way through the bewildering complexity of biological signaling pathways.

목차

Preface XXVII1 Basics of Cell Signaling 11.1 Cell Signaling: Why, When, and Where? 11.2 Intercellular Signaling 31.3 Hormones in Intercellular Signaling 81.4 Intracellular Signaling: Basics 151.5 Molecular Tools for Intracellular Signaling 182 Structural Properties, Regulation and Posttranslational Modification of Signaling Proteins 272.1 Modular Structure of Signaling Proteins 272.2 Modular Signaling Complexes 312.3 Regulation of Signaling Enzymes by Effector Binding 342.4 Posttranslational Modifications (PTMs) in Cellular Signaling 362.5 Regulation by Protein Phosphorylation 512.6 Regulation by Protein Lysine Acetylation 552.7 Regulation by Protein Methylation 582.8 Ubiquitin Modification of Proteins 622.9 Lipidation of Signaling Proteins 903 Organization of Signaling 1033.1 Scaffold Proteins 1033.2 Signal Processing in Signaling Paths and Signaling Networks 1083.3 Architecture of Signaling Pathways 1134 The Regulation of Gene Expression 1294.1 The Basic Steps of Gene Expression 1294.2 The Components of the Eukaryotic Transcription Machinery 1314.3 The Principles of Transcription Regulation 1494.4 The Control of Transcription Factors 1654.5 Chromatin Structure and Transcription Regulation 1755 RNA Processing, Translational Regulation, and RNA Interference 2095.1 Pre-mRNA Processing 2095.2 Regulation at the Level of Translation 2175.3 Regulation by RNA Silencing 2296 Signaling by Nuclear Receptors 2516.1 Ligands of Nuclear Receptors (NRs) 2526.2 Principles of Signaling by Nuclear Receptors (NRs) 2546.3 Structure of Nuclear Receptors (NRs) 2576.4 Transcriptional Regulation by NRs 2686.5 Regulation of Signaling by Nuclear Receptors 2746.6 Subcellular Localization of NRs 280

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저자(글) Gerhard Krauss

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Gerhard Krauss is Professor of Biochemistry at the University of Bayreuth (Germany). His resarch is centered on the mechanism of interaction of DNA binding proteins and their target DNA. He is also a gifted teacher and textbook author, and for many years has been the head of the university education committee of the German Society of Biochemistry and Molecular Biology (GBM).

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