Peptide Drug Discovery and Development

Miguel Castanho 지음

Wiley-VCH 2011년 10월 24일 출간

작품소개

책소개

Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the quot;bench to bedsidequot; translational approach to drug development.Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.

목차

PrefacePART I: The Academia -Market Bouncing of Peptide Drugs -Challenges and Strategies in Translational Research with Peptide DrugsPEPTIDES AS LEADS FOR DRUG DISCOVERYIntroductionOverview of Process for Transforming Peptides to PeptidomimeticsHCMV ProteaseHCV ProteaseHerpes Simplex VirusReninHIVConclusionsMARKETING ANTIMICROBIAL PEPTIDES: A CRITICAL ACADEMIC POINT OF VIEWIntroductionBasic Research: Antimicrobial PeptidesPatentsPotential Applications of AMPsTechnology Transfer: Valorization, Licensing, or Spin-Off CreationSpin-Off Creation: An Academic Point of ViewORAL PEPTIDE DRUG DELIVERY: STRATEGIES TO OVERCOME CHALLENGESIntroductionChallenges Associated with Oral Petide DeliveryStrategies to Overcome the Barriers of the Gastrointestinal TractConclusionsRATIONAL DESIGN OF AMPHIPATHIC ALPHA-HELICAL AND CYCLIC BETA-SHEET ANTIMICROBIAL PEPTIDES: SPECIFICITY AND THERAPEUTIC POTENTIALIntroduction to Antimicrobial PeptidesAntimicrobial and Hemolytic Activities of Amphipathic Alpha-Helical Antimicrobial Peptides: Mechanisms and SelectivityStructure-Activity Relationship Studies of Amphipathic Alpha-Helical and Cyclic Beta-Sheet Antimicrobial Peptides: Optimization of Pathogen Selectivity and Prevention of Host ToxicityCommercialization of Antimicrobial PeptidesTherapeutic PotentialCONOTOXIN-BASED LEADS IN DRUG DESIGNIntroductionConotoxin Classification and TargetsConotoxins as Drug LeadsConclusionsPLANT ANTIMICROBIAL PEPTIDES: FROM BASIC STRUCTURES TO APPLIED RESEARCHIntroductionThe Diversity of Plant Antimicrobial Peptides: Focusing on Tissue Localization and Plant Species DistributionPossible Structural Folds Found in Plant AMPs to DateNew Biotechnological Products Produced from Plant PeptidesPART II: Peptide Drugs' Translational Tales -Peptide Drugs Before, Through and

출판사 서평

“This book illustrates many of the technical prerequisites and describes model systems in which these objectives have been at least partially achieved.& &It convincingly shows that peptide-based drug discovery has become a mainstream activity in the drug discovery and development process.”& (ChemMedChem, 2012)&

작가정보

저자(글) Miguel Castanho

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Miguel Castanho is head of the Biochemistry department of the School of Medicine at the University of Lisbon (Portugal). He also leads the Physical Biochemistry research unit at the Institute of Molecular Medicine. His main field of research is the interaction of peptide drugs with lipids, in particular the role of lipid membranes in the mechanism of action of peptide drugs. Nuno C. Santos is the leader of the Biomembranes Unit of the Institute of Molecular Medicine. His research is centered on the specific functions of biological membranes lipids and proteins, with a special focus on their relevance for pathologic processes ranging from viral or bacterial infection to cardiovascular diseases.Together, Miguel Castanho and Nuno C. Santos have been involved in many collaborative drug discovery and development projects with industry partners in Europe, USA, Canada, and China.