Privileged Chiral Ligands and Catalysts

Qi-Lin Zhou 지음

Wiley-VCH 2011년 02월 10일 출간

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Catalytic asymmetric synthesis has been one of the most active research areas in chemistry (Nobel Prize in 2001). The development of efficient chiral catalysts plays a crucial role in asymmetric catalysis. Although many chiral ligands/catalysts have been developed in the past decades, the most efficient catalysts are derived from a few core structures, called quot;privileged chiral catalystsquot;. This ultimate quot;must havequot; and long awaited reference for every chemist working in the field of asymmetric catalysis starts with the core structure of the catalysts, explaining why a certain ligand or catalyst is so successful. It describes in detail the history, the basic structural characteristics, and the applications of these quot;privileged catalystsquot;. This novel presentation provides readers with a much deeper insight into the topic and makes it a must-have for organic chemists, catalytic chemists, chemists working with/on organometallics, chemists in industry, and libraries.From the contents:* BINAP* Bisphosphacycles - From DuPhos and BPE to a Diverse Set of Broadly Applied Ligands* Josiphos Ligands: From Discovery to Technical Applications* Chiral Spiro Ligands* Chiral Bisoxazoline Ligands* PHOX Ligands* Chiral Salen Complexes* BINOL* TADDOLate Ligands* Cinchona Alkaloids* Proline Derivatives

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PrefaceBINAPIntroduction: Structural ConsiderationHydrogenation of OlefinsHydrogenation of KetonesIsomerization of Allylamines and AllylalcoholsHydroboration, Hydrosilylation, Hydroacylation, and HydroaminationAllylic AlkylationHeck ReactionAldol and Mannich-Type ReactionsNucleophilic Additions to Carbonyl and Imino CompoundsAlpha-Substitution Reactions of Carbonyl CompoundsMichael-Type ReactionsConjugate Additions Using Organoboron and Grignard ReagentsDiels-Alder ReactionEne ReactionCyclizationRing-Opening ReactionsConcluding RemarksBISPHOSPHACYCLES -FROM DuPHOS AND BPE TO A DIVERSE SET OF BROADLY APPLIED LIGANDSIntroductionDevelopment of Bisphosphacycle LigandsApplications of Bisphosphacycle LigandsConcluding RemarksJOSIPHOS LIGANDS: FROM DISCOVERY TO TECHNICAL APPLICATIONSIntroduction and BackgroundDiscovery and Development of the Josiphos Ligand FamilyWhy Are Josiphos Ligands So Effective?Catalytic Profile of the Josiphos Ligand FamilyConcluding RemarksCHIRAL SPIRO LIGANDSIntroductionPreparation of Chiral Spiro LigandsAsymmetric HydrogenationAsymmetric Carbon-Carbon Bond Forming ReactionAsymmetric Carbon-Heteroatom Bond Forming ReactionConclusionCHIRAL BISOXAZOLINE LIGANDSIntroductionEnantioselective Carbon-Carbon Bond FormationEnantioselective Carbon-Heteroatom Bond FormationEnantioselective Cycloaddition ReactionsConclusionsPHOX LIGANDSIntroductionSynthesis of PHOX LigandsNucleophilic Allylic SubstitutionDecarboxylative Tsuji AllylationsHeck ReactionHydrogenationCycloadditionsMiscellaneous ReactionsConclusionCHIRAL SALEN COMPLEXESIntroductionSynthesis of Chiral Salen ComplexesStructural Properties of Chiral Salen ComplexesAsymmetric Reactions Catalyzed by Chiral Salen ComplexesConclusion and Outlook<

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저자(글) Qi-Lin Zhou

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Qi-Lin Zhou is the Director of the Institute of Elemento-organic Chemistry, Nankai University in Tianjin, China. He obtained his PhD degree at Shanghai Institute of Organic Chemistry. After several years of postdoctoral research (with professors Andreas Pfaltz and Michael Doyle et al.) he started his independent research in the field of asymmetric catalysis in China. Qi-Lin Zhou has authored over 100 scientific publications and has received many scientific awards including the Prize for Creation in Organic Synthesis (Chinese Chemical Society, Division of Organic Chemistry), Yao-Zeng Huang Prize of Organometallics (Chinese Chemical Society), and JSPS Fellowship Award (Japan Society for the Promotion of Science). He is also a member of different editorial boards such as Acc. Chem. Res..