CMOS Integrated Lab-on-a-chip System for Personalized Biomedical Diagnosis

Hao Yu , Mei Yan , Xiwei Huang 지음

Wiley-IEEE Press 2018년 04월 04일 출간

작품소개

책소개

이 책은 과학/기술분야 외국도서입니다.

목차

Preface xi 1 Introduction 1 1.1 Personalized Biomedical Diagnosis 1 1.1.1 Personalized Diagnosis 1 1.1.2 Conventional Biomedical Diagnostic Instruments 3 1.1.2.1 Optical Microscope 3 1.1.2.2 Flow Cytometer 4 1.1.2.3 DNA Sequencer 5 1.2 CMOS Sensor-based Lab-on-a-Chip for System Miniaturization 7 1.2.1 CMOS Sensor-based Lab-on-a-Chip 7 1.2.2 CMOS Sensor 8 1.2.2.1 CMOS Process Fundamentals 8 1.2.2.2 CMOS Sensor Technology 10 1.2.2.3 Multimodal CMOS Sensor 13 1.2.3 Microfluidics 14 1.2.3.1 Microfluidic Fundamentals 14 1.2.3.2 Microfluidics Fabrication 16 1.3 Objectives and Organization of this Book 20 1.3.1 Objectives 20 1.3.2 Organization 20 References 21 2 CMOS Sensor Design 25 2.1 Top Architecture 25 2.2 Noise Overview 25 2.2.1 Thermal Noise 26 2.2.2 Flicker Noise 27 2.2.3 Shot Noise 28 2.2.4 MOSFET Noise Model 29 2.3 Pixel Readout Circuit 29 2.3.1 Source Follower 30 2.3.2 Sub-threshold Gm Integrator 33 2.3.3 CTIA 35 2.4 Column Amplifier 38 2.5 Column ADC 39 2.5.1 Single-Slope ADC 39 2.5.2 Sigma-Delta ADC 43 2.6 Correlated Sampling 49 2.6.1 Correlated Double Sampling 49 2.6.2 Correlated Multiple Sampling 51 2.7 Timing Control 52 2.7.1 Row Timing Control 52 2.7.2 Column Timing Control 55 2.8 LVDS Interface 57 References 59 3 CMOS Impedance Sensor 60 3.1 Introduction 60 3.2 CMOS Impedance Pixel 61 3.3 Readout Circuit 63 3.4 A 96 × 96 Electronic Impedance Sensing System 65 3.4.1 Top Architecture 65 3.4.2 System Implementation 67 3.4.2.1 System Setup 67 3.4.2.2 Sample Preparation 68 3.4.3 Results 68 3.4.3.1 Data Fitting for Single Cell Impedance Measurement 69 3

작가정보

저자(글) Hao Yu

Dr. Hao Yu, Nanyang Technological University, Singapore, is an assistant professor and area director of the VIRTUS/VALENS Centre of Excellence. Dr. Mei Yan, Illumina, USA, developed lab-on-a-chip biomedical sensor circuits and systems for personalized biomedical diagnosis as a Research Fellow at Nanyang Technological University in Singapore. Dr. Xiwei Huang, Hangzhou Dianzi University, China, is an assistant professor at the School of Electronics and Information.

저자(글) Mei Yan

저자(글) Xiwei Huang