Protein Moonlighting in Biology and Medicine

Brian Henderson , Mario A. Fares , Andrew C. R. Martin 지음

Wiley-Blackwell 2016년 12월 12일 출간

작품소개

책소개

The past 25 years has seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as protein moonlighting. Moonlighting proteins can exhibit novel biological functions, thus extending the function of the proteome, and are also implicated in the pathology of a growing number of idiopathic and infectious diseases. This book, written by a cell biologist, protein evolutionary biologist and protein bioinformatician, brings together the latest information on the structure, evolution and biological function of the growing numbers of moonlighting proteins that have been identified, and their roles in human health and disease. This information is revealing the enormous importance protein moonlighting plays in the maintenance of human health and in the induction of disease pathology. Protein Moonlighting in Biology and Medicine will be of interest to a general readership in the biological and biomedical research community.

목차

Preface xi 1 An Introduction to the Protein Molecule 1 1.1 Why Study Protein Moonlighting? 1 1.2 A Brief History of Proteins 2 1.3 Protein Biology 4 1.4 Protein Structure and Function 6 1.5 Protein Sequence Determination, Structures, and Bioinformatics 9 1.6 Regulation of Protein Synthesis 11 1.7 Conclusions 12 References 12 2 How Proteins Evolve? 15 2.1 Introduction 15 2.2 A Darwinian View of Molecular Evolution 16 2.3 The Neutral and Nearly Neutral Theories of Molecular Evolution 18 2.4 Mutation, Fitness, and Evolution 20 2.5 Proteins Evolve at Different Rates 24 2.6 Protein Evolution by Gene Duplication 25 2.7 Conclusions 26 References 26 3 A Brief History of Protein Moonlighting 31 3.1 Introduction 31 3.2 Protein Moonlighting: The Early Beginnings 31 3.3 Eye Lens Proteins and Gene Sharing 33 3.4 Multifunctional Metabolic Proteins and Molecular Chaperones 35 3.5 The Return of Moonlighting 37 3.6 A Current View of Protein Moonlighting 39 3.7 The Current Population of Moonlighting Proteins 40 3.8 Conclusions 40 References 40 4 The Structural Basis of Protein Moonlighting 45 4.1 Introduction 45 4.2 The Structural Biology of Protein Moonlighting 48 4.2.1 Exploiting Protein Bulk 49 4.2.2 Catalytic Promiscuity 49 4.2.3 Exploiting Separate Functional Sites 50 4.2.4 Exploiting Alternatively Folded Forms 55 4.2.5 Alternative Oligomerization 56 4.2.6 Posttranslational Modifications 57 4.3 Predicting and Engineering Moonlighting 57 4.4 Conclusions 58 References 60 5 Protein Moonlighting and New Thoughts about Protein Evolution 63 5.1 Introduction 63 5.2 A Darwinian Perspective of Protein Moonlighting 65 5.3 Origin and Evolutionary Sta

작가정보

저자(글) Brian Henderson

저자(글) Mario A. Fares

저자(글) Andrew C. R. Martin