Introduction to Veterinary Genetics

Frank W. Nicholas 지음

Wiley-Blackwell 2013년 05월 30일 출간

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The concepts of veterinary genetics are crucial to understanding and controlling many diseases and disorders in animals. They are also crucial to enhancing animal production. Accessible and clearly presented, Introduction to Veterinary Genetics provides a succinct introduction to the aspects of genetics relevant to animal diseases and production. Now in its third edition, this is the only introductory level textbook on genetics that has been written specifically for veterinary and animal science students.Coverage includes: basic genetics, molecular biology, genomics, cytogenetics, immunogenetics, population genetics, quantitative genetics, biotechnology, and the use of molecular tools in the control of inherited disorders.This book describes in detail how genetics is being applied to artificial selection in animal production. It also covers the conservation of genetic diversity in both domesticated and wild animals.New for the Third Edition:End-of-chapter summaries provide quick recaps.Covers new topics: epigenetics, genomics and bioinformatics.Thoroughly revised according to recent advances in genetics.Introduction to Veterinary Genetics is still the only introductory genetics textbook for students of veterinary and animal science and will continue to be an indispensable reference tool for veterinary students and practitioners alike.

목차

Preface1 Basic geneticsChromosomesMeiosis and mitosisThe biochemistry of inheritanceWhat is a gene?Gene regulationMutationGenes, alleles, and lociSimple or Mendelian inheritanceLinkageInactivationTypes of DNAFurther readingAppendix 1.1 Banded karyotypes of domestic species2 Molecular biologyRestriction enzymesRecombinant DNA and DNA cloningComplementary DNADNA sequencingPolymerase chain reactionSouthern analysis and related technologiesDNA expression microarraysThe detection of variation in base sequenceVeterinary diagnosisVariable number of tandem repeats (VNTR), DNA fingerprints, and microsatellitesSingle nucleotide polymorphisms (SNPs)Copy number variation (CNV)Gene mappingWhole-genome sequence assemblyProduction of polypeptide from cloned DNATransgenesisAntisense technologyRNA interferenceFurther reading3 Single-gene disordersInborn errors of metabolismSex-limited inheritanceGenetic heterogeneity of diseaseType of gene action and type of diseasePhenocopiesA sample of single-gene disordersA revolution in mapping and identifying the causal mutation of single-gene disordersFurther readingAppendix 3.1 A sample of single-gene traits that have been characterized at the molecular level4 Chromosomal aberrationsAbnormal chromosome numberAbnormal chromosome structureChromosomal aberrations in cancerEvolution of karyotypesInterspecific hybridizationFreemartinsBiological basis of sexClassification of intersex 116A sample of chromosomal aberrationsFurther readingAppendix 4.1 A sample of chromosomal aberrations in animals5 Single genes in populationsGene and genotype frequenciesRandom matingThe Hardy&~Weinberg lawExtensions to the Hardy&~Weinberg lawSelection and mutationGenetic drift and the founder effectExtending population genetics

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저자(글) Frank W. Nicholas

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Frank Nicholas is Emeritus Professor of Animal Genetics in the Faculty of Veterinary Science at the University of Sydney. He has edited and co-authored several books about genetics and one about Charles Darwin, and he created and maintains Online Mendelian Inheritance of Animals (OMIA; omia.angis.org.au), a comparative knowledge-base of genetic disorders and other familial traits in non-laboratory animals.