Practical Methods for Biocatalysis and Biotransformations 3

John Whittall , Peter W. Sutton , Wolfgang Kroutil 지음

Wiley 2016년 02월 16일 출간

작품소개

책소개

Biocatalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech enzymes and whole cell biocatalysts, which add enormously to the repertoire of synthetic possibilities. Practical Methods for Biocatalysis and Biotransformations 3 will be a companion book to Practical Methods for Biocatalysis and Biotransformations (2009) and Practical Methods for Biocatalysis and Biotransformations 2 (2012). Following the successful format of the two volumes, it will be a “how-to” guide focusing on commercially available enzymes and strains of microorganisms that are readily obtained from culture collections. The source of starting materials and reagents, hints, tips and safety advice (where appropriate) will be given to ensure, as far as possible, that the procedures are reproducible. Comparisons to alternative methodology will be given and relevant references to the primary literature will be cited. Contents include: Biotransformation Process Technology Industrial Biooxidation Hydrolase catalysed hydrolysis/synthesis Reduction Oxidation Halogenation Transferase catalysed glycosylation, methylation, etc C-C bond formation Tandem Biocatalytic Reactions Practical Methods for Biocatalysis and Biotransformations, Volume 3 is an essential collection of validated biocatalytic methods which will find a place on the bookshelves of synthetic organic chemists, pharmaceutical chemists, and process R&D chemists in industry and academia.

목차

List of ContributorsAbbreviations1 Considerations for the Application of Process Technologies for Laboratory and Pilot-Scale Biocatalysis for Chemical SynthesisHemalata Ramesh, Mathias Nordblad, John Whittall and John M. Woodley2 Cytochrome P450 (CYP) progress in biocatalysis for synthetic organic chemistryThomas S Moody and Steve JC Taylor3 Use of Hydrolases and Related Enzymes for Synthesis3.1 Continuous-flow reactor-based enzymatic synthesis of phosphorylated compounds on a large scaleLara Babich, Aloysius F. Hartog, Michael A. van der Horst, and Ron Wever3.2 Deracemisation of sec-alcohols via enantio-convergent hydrolysis of rac-sulfate estersMichael Toesch, Markus Schober and Kurt Faber3.3 Dynamic Kinetic Resolution of a Primary Amine by an Efficient Bifunctional Pd-CALB Hybrid Catalyst. A Metalloenzyme Mimic for Enhanced Cooperative CatalysisOscar Verho, Karl P. J. Gustafson and Jan-E. B ckvall3.4 Highly efficient dynamic kinetic resolution of secondary 1-phenylethanol derivatives using a low cost solid super acid as racemization catalystGang Xu, Jian-Ping Wu, Yong-Jun Chen, Liang Wang, Xiao Meng and Li-Rong Yang3.5 Identification of new biocatalysts for the enantioselective conversion of tertiary alcoholsRobert Kourist, Susanne Herter and Uwe T. Bornscheuer3.6 Enzyme catalyzed hydrolysis of bicycloheptane diester to monoesterZhiwei Guo, Michael Kwok Y Wong, Matthew R Hickey, Bharat P Patel, Xinhua Qian and Animesh Goswami3.7 A Double Mutant Lipase with Enhanced Activity and Enantioselectivity for Bulky Secondary AlcoholsTadashi Ema, Shusuke Kamata, Yasuko Nakano, Daiki Yoshida and Takashi Sakai

작가정보

저자(글) John Whittall

저자(글) Peter W. Sutton

저자(글) Wolfgang Kroutil