The Art of Drug Synthesis

Douglas S. Johnson 지음

Wiley-Interscience 2013년 02월 26일 출간

작품소개

책소개

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis.Edited by prominent scientists working in drug discovery for PfizerMeets the needs of a growing community of researchers in pharmaceutical RDProvides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry studentsAn excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

목차

Foreword.Preface.Contributors.1 THE ROLE OF MEDICINAL CHEMISTRY IN DRUG DISCOVERY (John A. Lowe, III).1.1 Introduction.1.2 Hurdles in the Drug Discovery Process.1.3 The Tools of Medicinal Chemistry.1.3.1 In Silico Modeling.1.3.2 Structure-Based Drug Design (SBDD).1.4 The Role of Synthetic Chemistry in Drug Discovery.References.2 PROCESS RESEARCH: HOW MUCH? HOW SOON? (Neal G. Anderson).2.1 Introduction.2.2 Considerations for Successful Scale-up to Tox Batches and Phase I Material.2.3 Considerations for Phase 2 Material and Beyond.2.3.1 Reagent Selection.2.3.2 Solvent Selection.2.3.3 Unit Operations.2.3.4 Developing Simple, Effective, Efficient Work-ups and Isolations.2.3.5 The Importance of Physical States.2.3.6 Route Design and Process Optimization to Minimize COG.2.4 Summary.References.I CANCER AND INFECTIOUS DISEASES.3 AROMATASE INHIBITORS FOR BREAST CANCER: EXEMESTANE (AROMASIN), ANASTROZOLE (ARIMIDEX), AND LETROZOLE (FEMARA) (Jie Jack Li).3.1 Introduction.3.2 Synthesis of Exemestane.3.3 Synthesis of Anastrozole.3.4 Synthesis of Letrozole.References.4 QUINOLONE ANTIBIOTICS: LEVOFLOXACIN (LEVAQUIN), MOXIFLOXACIN (AVELOX), GEMIFLOXACIN (FACTIVE), AND GARENOXACIN (T-3811) (Chris Limberakis).4.1 Introduction.4.1.1 Mechanism of Action.4.1.2 Modes of Resistance.4.1.3 Structure&~Activity Relationship (SAR) and Structure&~Toxicity Relationship (STR).4.1.4 Pharmacokinetics.4.1.5 Synthetic Approaches.4.2 Levofloxacin.4.3 Moxifloxacin.4.4 Gemifloxacin.4.5 Garenoxacin (T-3811): A Promising Clinical Candidate.References.5 TRIAZOLE ANTIFUNGALS: ITRACONAZOLE (SPORANOX), FLUCONAZOLE (DIFLUCAN), VORICONAZOLE (VFEND), AND FOSFLUCONAZOLE (PRODIF) (Andrew S. Bell).5.1 Introduction.5.2 Synthesis of Itraconazole.5.3 Synthesis of Fluconazole.5.4 Synthesis of Voriconazole.5.5 Synthesis of Fosfluconazole.References.6 NON-NUCLE

출판사 서평

&"This is a most topical and useful short primer on estab1ished drugs and their synthesis.&" (American Journal of Therapeutics, June 2009)"The book is very felicitous and closes a gap in the literature by covering the subject of drug development in this particular way." (Angewandte Chemie, June 23, 2008)"This book is a very entertaining read." (ChemMedChem, 2008, 3)"The editors and contriubting authros have certainly provided a most useful book for the medicinal and organic chemistry community." (Journal of Medicinal Chemistry, March 2008)"Where I see the book being very useful is as a starting point for student seminars or discussion groups... Also, it is highly illuminating just to dip into for a browse and to marvel at some of the excellent chemistry that goes on in the pharmaceutical industry." (Chemistry World, January 2008)

작가정보

저자(글) Douglas S. Johnson

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Douglas S. Johnson, PHD, is a Research Chemist at Pfizer Global Research and Development.Jie Jack Li, PHD, is a Research Chemist at Pfizer Global Research and Development.