Neural Dynamics of Neurological Disease

Christopher A. Shaw 지음

Wiley-Blackwell 2017년 02월 03일 출간

작품소개

책소개

The emerging understanding of age-related neurological disorders suggeststhat notions of a single causal gene/toxin being responsible is likely incorrect. Neurological disorders likely arise due to a unique intersection of multiple genetic and toxic factors combined with additional contributions of age, stage of development, immune system actions, and more. This perspective leads to the view that rather than reflecting only one pathway to end state disease, each is a spectrum disorder and each individual case is therefore unique. Neural Dynamics of Neurological Disease argues for a fundamental rethinking of what we think we know about neurological disorders, how these arise and progress and, crucially, what might be done to “cure” them. Chapters first introduce the concept of neural dynamics of neurological disease, then examine various diseases and give examples of the interplay of elements such as neural systems, cell types, and biochemical pathways which can contribute to disease. Concluding chapters point the way forward to how the emerging notion of neurological disease as a dynamic process may lead to more successful treatment options. Providing a cross disciplinary approach to understanding the origin and progression of neurological disease, Neural Dynamics of Neurological Disease is a timely and valuable resource for neuroscientists, researchers and clinicians. About the AuthorChristopher A. Shaw Department of Ophthalmology and Visual Sciences, University of British Columbia, Canada

목차

List of Figures List of Tables Preface Acknowledgments Part I The Dynamics of Neurological Disease 1 The Dynamics of Neurological Disease: Current Views and Key Issues 1.1 From the Preface 1.2 The Complexity of Human Neurological Diseases 1.3 The Nervous System as an Archetypical Complex System 1.4 CNS Signaling Failures: Implications for Neurological Disease 1.5 History and Key Characteristics of the Age-Dependent Neurological Diseases 1.6 The Fractal Nature of Complexity in the CNS 2 Clinical and Economic Features of Age-Related Neurological Diseases 2.1 From the Preface 2.2 Parkinson’s Disease 2.2.1 Neuropathological Features 2.2.2 The Parkinsonisms 2.2.3 Rating Schemes 2.2.3.1 Hoehn and Yahr Scale 2.2.3.2 Modified Hoehn and Yahr Scale 2.2.3.3 Schwab and England Activities of Daily Living Scale 2.2.3.4 Unified Parkinson’s Disease Rating Scale 2.2.4 Progression 2.2.5 Other Organ System Involvement 2.2.6 Parkinson’s Disease Clusters 2.2.7 Risk Factors 2.2.8 Current Treatment Options 2.2.9 Animal Models 2.2.10 Parkinson’s Disease in Relation to Other Neurological Diseases 2.2.11 Demographics 2.2.12 Incidence and Prevalence 2.2.12.1 United States and Canada 2.2.12.2 Worldwide 2.2.13 Changes in Incidence/Prevalence over the Last 30 Years 2.2.13.1 United States and Canada 2.2.14 Costs 2.2.14.1 Cost Per Patient 2.2.14.2 Societal Costs 2.2.14.3 Projected Cost Increases 2.3 Amyotrophic Lateral Sclerosis 2.3.1 Loci of Onset 2.3.2 Neuropathological Features 2.3.3 Rating Schemes 2.3.3.1 El Escorial Diagnostic Criteria 2.3.3.2 ALS Functional Rating Scale 2.3.3.3 Forced Vital Capacity 2.3.4 Progression 2.3.5 Rates of Disease Progr

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저자(글) Christopher A. Shaw