Molecular Pharmacology

John Dickenson 지음

Wiley 2012년 11월 30일 출간

작품소개

책소개

This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of lsquo;trial and error' drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data.Cutting Edge - highlights advances in pharmacogenomics and explores how an individual's genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects.Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect.Accessible - contains a comprehensive glossary, suggestions fo

목차

Preface ixAbbreviations x1 Introduction to Drug Targets and Molecular Pharmacology 11.1 Introduction to molecular pharmacology 11.2 Scope of this textbook 21.3 The nature of drug targets 31.4 Future drug targets 71.5 Molecular pharmacology and drug discovery 11References 122 Molecular Cloning of Drug Targets 132.1 Introduction to molecular cloning &n- from DNA to drug discovery 132.2 ‘Traditional&' pharmacology 142.3 The relevance of recombinant DNA technology to pharmacology/drugdiscovery 142.4 The ‘cloning&' of drug targets 152.5 What information can DNA cloning provide? 202.6 Comparing the pharmacologic profile of the ‘cloned&' and the ‘native&'drug target 232.7 Reverse pharmacology illustrated on orphan GPCRs 242.8 Summary 27References 273 G Protein-coupled Receptors 313.1 Introduction to G protein-coupled receptors 313.2 Heterotrimeric G-proteins 363.3 Signal transduction pathways 403.4 Desensitisation and down-regulation of GPCR signalling 443.5 Constitutive GPCR activity 453.6 Promiscuous G-protein coupling 473.7 Agonist-directed signalling 483.8 Allosteric modulators of GPCR function 493.9 Pharmacological chaperones for GPCRs 503.10 GPCR dimerisation 513.11 GPCR splice variants 633.12 Summary 67References 67Useful Web sites 704 Ion Channels 714.1 Introduction 714.2 Voltage-gated ion channels 734.3 Other types of voltage-gated ion channels 894.4 Ligand-gated ion channels 1094.5 Summary 125References 1255 Transporter Proteins 1295.1 Introduction 1295.2 Classification 1295.3 Structural analysis of transporters 1325.4 Transporter families of pharmacological interest 1335.5 Transporters and

출판사 서평

“Overall, it could be the basis of an excellent course for junior pharmacologists in basic science research who need a greater focus on the mechanisms of drug action rather than an encyclopedic survey of clinical drug use.”& (Doody&'s, 26 July 2013)

작가정보

저자(글) John Dickenson