Catalytic Cascade Reactions

Peng-Fei Xu 지음

Wiley 2013년 12월 30일 출간

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Demonstrates the advantages of catalytic cascade reactions for synthesizing natural products and pharmaceuticalsRiding the wave of green chemistry, catalytic cascade reactions have become one of the most active research areas in organic synthesis. During a cascade reaction, just one reaction solvent, one workup procedure, and one purification step are needed, thus significantly increasing synthetic efficiency.Featuring contributions from an international team of pioneers in the field, Catalytic Cascade Reactions demonstrates the versatility and application of these reactions for synthesizing valuable compounds. The book examines both organocatalysis and transition#45;metal catalysis reactions, bringing readers up to date with the latest discoveries and activities in all major areas of catalytic cascade reaction research.Catalytic Cascade Reactions begins with three chapters dedicated to organocatalytic cascade reactions, exploring amines, Broslash;nsted acids, and the application of organocatalytic cascade reactions in natural product synthesis and drug discovery. Next, the book covers:Gold#45;catalyzed cascade reactionsCascade reactions catalyzed by ruthenium, iron, iridium, rhodium, and copperPalladium#45;catalyzed cascade reactions of alkenes, alkynes, and allenesApplication of transition#45;metal catalyzed cascade reactions in natural product synthesis and drug discoveryEngineering mono#45; and multifunctional nanocatalysts for cascade reactionsMultiple#45;catalyst#45;promoted cascade reactionsAll chapters are thoroughly referenced, providing quick access to important original research findings and reviews so that readers can explore individual topics in greater depth.Drawing together and analyzing published findings scattered across the literature, this book provides a single source that encapsulates our current understanding of catalytic cascade pr

목차

Contributors xiPreface xiii1 Amine-Catalyzed Cascade Reactions 1Aiguo Song and Wei Wang1.1 Introduction, 21.2 Enamine-Activated Cascade Reactions, 31.2.1 Enamine&n-Enamine Cascades, 31.2.2 Enamine&n-Iminium Cascades, 81.2.3 Enamine Catalysis Cyclization, 191.3 Iminium-Initiated Cascade Reactions, 211.3.1 Design of Iminium&n-Enamine Cascade Reactions, 211.3.2 Iminium-Activated Diels&n-Alder Reactions, 221.3.3 Iminium-Activated Sequential [4 + 2] Reactions, 241.3.4 Iminium-Activated [3 + 2] Reactions, 251.3.5 Iminium-Activated Sequential [3 + 2] Reactions, 271.3.6 Iminium-Activated [2 + 1] Reactions, 301.3.7 Iminium-Activated Multicomponent Reactions, 351.3.8 Iminium-Activated [3 + 3] Reactions, 371.4 Cycle-Specific Catalysis Cascades, 421.5 Other Strategies, 451.6 Summary and Outlook, 46References, 462 Brønsted Acid&n-Catalyzed Cascade Reactions 53Jun Jiang and Liu-Zhu Gong2.1 Introduction, 542.2 Protonic Acid&n-Catalyzed Cascade Reactions, 552.2.1 Mannich Reaction, 552.2.2 Pictect&n-Spengler Reaction, 562.2.3 Biginelli Reaction, 582.2.4 Povarov Reaction, 592.2.5 Reduction Reaction, 602.2.6 1,3-Dipolar Cycloaddition, 612.2.7 Darzen Reaction, 652.2.8 Acyclic Aminal and Hemiaminal Synthesis, 662.2.9 Rearrangement Reaction, 672.2.10 a,b-Unsaturated Imine-Involved Cyclization Reaction, 692.2.11 Alkylation Reaction, 692.2.12 Desymmetrization Reaction, 702.2.13 Halocyclization, 712.2.14 Redox Reaction, 722.2.15 Isocyanide-Involved Multicomponent Reaction, 732.2.16 Other Protonic Acid&n-Catalyzed Cascade Reactions, 752.3 Chiral Thiourea (Urea)&n-Catalyzed Cascade Reactions, 752.3.1 Neutral Activation, 762.3.2 Anion

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저자(글) Peng-Fei Xu

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PENG#45;FEI XU, PhD, is Director of Teaching Affairs and Professor of Chemistry at Lanzhou University and Deputy Director at the State Key Laboratory of Applied Organic Chemistry. Dr. Xu also serves as an Advisory Board member for the Chinese Chemical Society. During his scientific career, he has published more than 130 papers and received numerous honors and awards, most recently the Award of New Century Excellent Talents in Universities of China and the Thieme Journal Award.WEI WANG, PhD, is Professor of Chemistry at the University of New Mexico. Dr. Wang has published more than 160 peer#45;reviewed papers. He has received several awards, including The Creative Award from University of New Mexico, The Chinese#45;American Chemistry #38; Chemical Biology Professors Association Distinguished Junior Faculty Award, and The American Peptide Society Bruce W. Erickson Young Investigator Award.