Endocrine Disrupters

Peter Matthiessen 지음

Wiley 2013년 02월 04일 출간

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Enables researchers to assess the effects of endocrine disrupters as well as comply with new environmental regulationsEndocrine disrupters are chemicals#151;both man#45;made and natural#151;that interfere with the body#39;s endocrine system, potentially resulting in adverse developmental, reproductive, neurological, and immune effects. In recent years, a number of regulatory authorities around the world have drafted or enacted legislation that requires the detection and assessment of the effects of endocrine disrupters on both humans and wildlife. In response, this book provides comprehensive, up#45;to#45;date information on the latest tested and proven methods used to detect and assess the environmental hazards posed by endocrine#45;disrupting chemicals.Endocrine Disrupters is divided into chapters covering each major taxon as well as chapters dedicated to hazard assessment and regulation. The book covers testing methods for all the vertebrate groups and several invertebrate phyla, including:Crustaceans and mollusksInsectsFishAmphibians and reptilesBirds and mammalsMoreover, the book emphasizes practical, ethical testing methods that combine sensitivity, efficiency, statistical power, and reasonable cost.Each chapter is written by one or more international experts in ecotoxicology, offering readers step#45;by#45;step guidance for implementing each method based on the latest research and the authors#39; firsthand laboratory experience. Furthermore, all the chapters have been subjected to a rigorous peer review and edited in light of the reviewers#39; comments. References at the end of each chapter guide readers to the literature in the field.Endocrine Disrupters is recommended for scientists who need to test chemicals for possible endocrine#45;disrupting properties. It is also recommended for regulatory authorities who need to decide whether particular chemic

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Preface ixContributors xi1 Ecotoxicity Test Methods for Endocrine-Disrupting Chemicals: An Introduction 1Peter Matthiessen1.1 Background 11.2 Regulatory Concerns 21.3 Invertebrates 21.4 Vertebrates 31.5 Testing Schemes for EDCs 5Reference 62 Endocrine Disruption inWildlife: Background, Effects, and Implications 7Dick Vethaak and Juliette Legler2.1 Background to Endocrine Disruption 82.2 Effects of EDCs on Wildlife 192.3 Weight of Evidence and Ecological Significance of ED Effects 322.4 Implications for Effect Assessment and Toxicity Testing 362.5 Need for More Field Studies and an Integrated Approach 382.6 Concluding Points 39References 403 The Regulatory Need for Tests to Detect EDCs and Assess Their Hazards toWildlife 59Hans-Christian Stolzenberg, Tobias Frische, Vicki L. Dellarco, Gary Timm, Anne Gourmelon, Taisen Iguchi, Flemming Ingerslev, and Mike Roberts3.1 Emerging Concerns and Policy Responses: Focusing on EDCs as a Large Pseudo-Uniform Group of Substances 603.2 General Approaches in Substance-Related Regulatory Frameworks (EU) 803.3 How to Make EDC Definitions Operational for Substance-Related Regulatory Work 873.4 Future Perspectives 913.5 Conclusions 92References 934 Techniques for Measuring Endocrine Disruption in Insects 100Lennart Weltje4.1 Introduction 1004.2 Methods 1054.3 Discussion 1084.4 Conclusion 1104.5 Acknowledgments 110References 1105 Crustaceans 116Magnus Breitholtz5.1 Introduction 1165.2 Background to Crustacean Endocrinology 1185.3 State of the Art: What Do We Know About Endocrine Disruption in Crustaceans? 1215.4 Available Subchronic/Chronic Standard Test Protocols 1285.5 Complementary Too

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저자(글) Peter Matthiessen

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PETER MATTHIESSEN, PhD, is an aquatic ecotoxicologist who works as an independent consultant. Specializing in the study of endocrine disrupters, he has conducted extensive research into how sewage effluents cause feminization in wild male fish as well as how tributyltin#45;based antifoulants cause masculinization in wild female mollusks. Professor Matthiessen is a member of the UK Advisory Committee on Pesticides and Co#45;chair of the OECD Validation Management Group for Ecotoxicity Tests. He has contributed to the development of standardized ecotoxicity assays with sensitivity for endocrine disrupters as well as written guidance for the interpretation of the resulting data.