Drug Discovery

Jie Jack Li 지음

Wiley 2013년 04월 12일 출간

작품소개

책소개

Sets forth the history, state of the science, and future directions of drug discoveryEdited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design.Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as:Target identification and validationDrug metabolism and pharmacokineticsCentral nervous system drugsIn vitro and in vivo assaysCardiovascular drugsCancer drugsEach chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field.Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.

목차

Chapter 1. History of Drug Discovery 11. Introduction 12. Antibacterials 13. Cancer Drugs 64. Cardiovascular Drugs 105. Cholesterol Drugs 166. CNS Drugs 217. Anti-inflammatory Drugs 268. Anti-ulcer Drugs 309. Antiviral Drugs 3310. References 38Chapter 2. Target Identification and Validation 431. History 432. Definition of Drug Targets 433. Classification of Currently Utilized Drug Targets 454. Receptors as Drug Targets 465. Enzymes as Drug Targets 486. Transporter Proteins as Drug Targets 497. Modern Technologies Employed in Target Identification and Validation 498. Impact of Therapeutic Modalities on the Selection Drug Targets 629. Future Directions 6310. References3. In vitro and in vivo Assays 671. Introduction 672. The Testing Funnel 673. In vitro assays 704. In vivo Assays 895. Outlook 926. References 93Chapter 4. Drug Metabolism and Pharmacokinetics in Drug Discovery 951. Introduction 952. Drug Metabolism 973. Pharmacokinetic Fundamentals 1064. Drug Metabolism and Pharmacokinetics in Drug Discovery 951. Introduction 952. Drug Metabolism 973. Pharmacokinetic Fundamentals 1064. Pharmacokinetics Studies in Support of Drug Optimization 1125. Absorption and Permeability 1146. Drug Transporters 1177. Protein Binding 1198. Pharmacokinetics and Pharmacodynamics 1239. Predicting Human Pharmacokinetics 13010. Summary 13311. References 133Chapter 5. Cardiovascular Drugs 1371. Introduction 1372. Early History of Coronary Heart Disease (CHD) 1383. Lipid Lowering Agents 1394. Antihypertensive Agents 1535. Antithrombotic Drugs 1776. Thrombolytic Agents 1907. Anti-anginal Ag

출판사 서평

“Taken together, the book is an excellent introduction into drug discovery and an eminent summary of the very important milestones of drug discovery in the most critical indication areas. This book is a valuable addition to the library of all different kinds of scientists working in the field of drug discovery.”& (ChemMedChem, 1 October 2013)

작가정보

저자(글) Jie Jack Li

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JIE JACK LI, PhD, is a chemist at Bristol#45;Myers Squibb Company. He has authored or edited several books published by Wiley, including Name Reactions in Heterocyclic Chemistry, Name Reactions for Functional Group Transformations, Name Reactions for Homologations (Part I and Part II), Name Reactions for Carbocyclic Ring Formations, Contemporary Drug Synthesis, The Art of Drug Synthesis, and Modern Drug Synthesis.E. J. COREY, PhD, has been a Professor at Harvard University since 1959. The 1990 Nobel Laureate in Chemistry, Dr. Corey has also been the recipient of more than seventy international awards and honorary degrees, including the U.S. National Medal of Science, the Japan Prize in Science, and the Priestley Medal. Author of more than 1,500 publications, he is one of the most cited authors in science.